FMOC-ASP-ODMAB

ChemicalBook > CAS DataBase List > FMOC-ASP-ODMAB

Product Name: FMOC-ASP-ODMAB
CAS No.: 172611-77-7
Chemical Name: FMOC-ASP-ODMAB
Synonyms: FMOC-ASP-ODMAB;Fmoc-L-Asp-ODmab;FMOC-ASP-ODMAB 5 G;(9H-Fluoren-9-yl)MethOxy]Carbonyl Asp-ODmab;Fmoc-L-aspartic acid α-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzyl ester;Fmoc-L-aspartic acid alpha-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzyl ester;FMOC-L-ASPARTIC ACID ALPHA-4-[N-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEXYLIDENE)-3-METHYLBUTYL]AMINO]BENZYL ESTER;N-ALPHA-FMOC-L-ASPARTIC ACID ALPHA-4-[N-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEXYLIDENE)-3-METHYLBUTYL]-AMINO] BENZYL ESTER;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 1-[[4-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]phenyl]methyl] ester;L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-[[4-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]phenyl]methyl] ester
CBNumber: CB2713809
Molecular Formula: C39H42N2O8
Formula Weight: 666.76
MOL File: Mol file

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FMOC-ASP-ODMAB Property

Boiling point:: 838.4±65.0 °C(Predicted)
Density: 1.264±0.06 g/cm3(Predicted)
storage temp.: Store at -15°C to -25°C.
pka: 4.01±0.19(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52079
Product name: Fmoc-Asp-ODmab
Purity: Novabiochem?
Packaging: 1G
Price: $264
Updated: 2023/06/20

Sigma-Aldrich

Product number: 8.52079
Product name: Fmoc-Asp-ODmab
Purity: Novabiochem?
Packaging: 5G
Price: $1050
Updated: 2023/06/20

Chem-Impex

Product number: 03693
Product name: Fmoc-L-asparticacidα-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzylester,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 250MG
Price: $84
Updated: 2021/12/16

AK Scientific

Product number: Y3369
Product name: Fmoc-Asp-ODMab
Packaging: 250mg
Price: $151
Updated: 2021/12/16

Chem-Impex

Product number: 03693
Product name: Fmoc-L-asparticacidα-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzylester,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 1G
Price: $173.6
Updated: 2021/12/16

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FMOC-ASP-ODMAB Chemical Properties,Usage,Production

Chemical Properties

FMOC-ASP-ODMAB is Yellow powder

Uses

The Dmab group can be cleaved selectively in the presence of tBu-based protected groups by treatment with 2% hydrazine in DMF, making this derivative an extremely useful tool for the preparation of cyclic peptides by FMOC SPPS

General Description

Quasi-orthogonally-protected Asp derivative.

The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis.

Occasionally sluggish cleavage of the aminobenzyl moiety is observed [2, 3]. In these instances, washing the support with 20% DIPEA in DMF/water (9:1) [2] or HCl in dioxane [4] has been found to be efficacious.

For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Asp(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.

To avoid aspartimide formation, it is advisable to employ an Hmb- or Dmb-protected derivative for introduction of the preceding residue.

For applications of this derivative in the synthesis of cyclic peptides, see references [5 - 7].

The product number for this product was previously 04-12-1176.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

FMOC-ASP-ODMAB Preparation Products And Raw materials

Raw materials

Preparation Products

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172611-77-7, FMOC-ASP-ODMABRelated Search:

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FMOC-ASP-ODMAB

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FMOC-ASP-ODMAB 5 G

Fmoc-L-aspartic acid α-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzyl ester

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((4-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino)benzyl)oxy)-4-oxobutanoic acid

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172611-77-7