1-(4-Fluorophenyl)piperazine

Product Name: 1-(4-Fluorophenyl)piperazine
CAS No.: 2252-63-3
Chemical Name: 1-(4-Fluorophenyl)piperazine
Synonyms: MONA-004;AKOS BBS-00003614;RARECHEM AH CK 0104;TIMTEC-BB SBB000218;LABOTEST-BB LT00053495;FLUOROPHENYL PIPERAZINE;p-Fluorophenylpiperazine;4-FLUOROPHENYLPIPERAZINE;N-(p-Fluorophenyl)piperazine;4-(4-Fluorophenyl)piperazine
CBNumber: CB2725068
Molecular Formula: C10H13FN2
Formula Weight: 180.22
MOL File: 2252-63-3.mol

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1-(4-Fluorophenyl)piperazine Property

Melting point:: 30-33 °C (lit.)
Boiling point:: 118-123 °C/0.1 mmHg (lit.)
Density: 1.0
refractive index: 1.5585-1.5605
Flash point:: >230 °F
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Liquid After Melting
pka: 8.93±0.10(Predicted)
color: Clear yellow
Water Solubility: Insoluble in water.
Sensitive: Air Sensitive
BRN: 610723
InChI: 1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
InChIKey: AVJKDKWRVSSJPK-UHFFFAOYSA-N
SMILES: Fc1ccc(cc1)N2CCNCC2
CAS DataBase Reference: 2252-63-3(CAS DataBase Reference)
NIST Chemistry Reference: 1-(P-fluorophenyl)piperazine(2252-63-3)

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Safety

Hazard Codes: Xn,T,C
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36
RIDADR: 2811
WGK Germany: 2
Hazard Note: Toxic/Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 037455
Product name: 1-(4-Fluorophenyl)piperazine
Purity: 95+%
Packaging: 5g
Price: $14
Updated: 2021/12/16

Matrix Scientific

Product number: 037455
Product name: 1-(4-Fluorophenyl)piperazine
Purity: 95+%
Packaging: 25g
Price: $54
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0015223
Product name: 1-(4-FLUOROPHENYL)PIPERAZINE
Purity: 95.00%
Packaging: 1G
Price: $704.55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0015223
Product name: 1-(4-FLUOROPHENYL)PIPERAZINE
Purity: 95.00%
Packaging: 10G
Price: $2055.9
Updated: 2021/12/16

Atlantic Research Chemicals

Product number: AN001605
Product name: 1-(4-Fluorophenyl)Piperazine
Purity: 95%
Packaging: 250mgs:
Price: $13.43
Updated: 2021/12/16

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1-(4-Fluorophenyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

clear yellowish liquid after melting

Uses

1-(4-Fluorophenyl)piperazine was used in the synthesis of N,N-disubstituted piperazine. It is a major metabolite of niaparazine, a sedative, a hypnotic drug.

Uses

1-(4-Fluorophenyl)piperazine is a major metabolite of Niaparazine, a sedative, hypnotic drug. Metabolites of Niaprazine occurred by N-dealkylation, N-dearylation, aromatic hydroxylation and N-oxidatio n.

Synthesis

Weighing 4-fluoroaniline 9.2mL (0.10mol), bis(2-chloroethyl)amine hydrochloride 17.85g (0.10mol) and diethylene glycol monomethyl ether 25mL in a 100mL three-necked flask, and placed in the reflux device equipped with a reflux device WBFY-201-type microcomputer microwave chemical reactor, reflux, the microwave radiation power of 800W, the reaction time is 3min. At the end of the reaction, the reaction solution was cooled and then distilled under reduced pressure to remove diethylene glycol monomethyl ether, and the solvent was recovered for use. The residue was added to a small amount of ethanol, add a certain amount of ether solution, to be clarified by the mixture, at this time, a large number of solids precipitated, the hydrochloride was dissolved in 30mL of water, the PH value was adjusted to 12 with 40% sodium hydroxide, ethyl acetate extraction for 2 times (2 40mL), and then washed with water and saturated saline respectively for 1 time, the organic layer was dried with anhydrous sodium sulfate, filtered, concentrated, and then obtained by distillation under reduced pressure 1- (4-fluorophenyl)piperazine light yellow liquid 13.97g, yield 77.6%.

1-(4-Fluorophenyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Fluorophenyl)piperazine Suppliers

Belgium 2 Canada 1 China 152 Europe 2 France 1 Germany 10 India 13 Italy 2 Japan 4 Slovakia 1 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 13 United States 32 Global 237

Hebei Fanbo Pharmaceutical Technology Co., Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 1-(4-Fluorophenyl)piperazine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(4-Fluorophenyl)piperazine 2252-63-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Career Henan Chemical Co

Product: 1-(4-Fluorophenyl)piperazine 2252-63-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-20

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MONA-004

2252-63-3

C10H13N2F

C10H14FN2

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