Abstract Efficacy Side effects References
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Citalopram hydrobromide

Abstract Efficacy Side effects References
Product Name
Citalopram hydrobromide
CAS No.
59729-32-7
Chemical Name
Citalopram hydrobromide
Synonyms
CITALOPRAM HBR;ERDOSTEIN;Citalopram hydrogen bromide;Citalopram for system suitability CRS;Bonitrile HBr;Lu 10-171 HBr;Citalopran HBr;Citalopram-D4Br;CitalopraM HBr API;Citalopram HBr Salt
CBNumber
CB2736240
Molecular Formula
C20H22BrFN2O
Formula Weight
405.3
MOL File
59729-32-7.mol
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Citalopram hydrobromide Property

Melting point:
182-188°C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: soluble (sparingly)
form 
powder
color 
White
Water Solubility 
Soluble to 50 mM in ethanol and to 10 mM in water
Merck 
14,2318
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
59729-32-7(CAS DataBase Reference)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25-22
Safety Statements 
7-16-36/37-45-24/25
RIDADR 
3249
WGK Germany 
3
RTECS 
NP6313500
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C-095
Product name
Citalopram hydrobromide solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
C-057
Product name
Citalopram hydrobromide solution
Purity
100?μg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$72
Updated
2024/03/01
Sigma-Aldrich
Product number
5.06238
Product name
Citalopram Hydrobromide - CAS 59729-32-7 - Calbiochem
Packaging
25MG
Price
$239
Updated
2024/03/01
Sigma-Aldrich
Product number
1134233
Product name
Citalopram hydrobromide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$877
Updated
2024/03/01
TCI Chemical
Product number
C2370
Product name
Citalopram Hydrobromide
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$91
Updated
2024/03/01
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Citalopram hydrobromide Chemical Properties,Usage,Production

Abstract

Citalopram hydrobromide (citalopram HBr) is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other available antidepressant agents.
Citalopram HBr occurs as a fine, white to off-white powder. Citalopram HBr is sparingly soluble in water and soluble in ethanol.
The tablet is available as the brand-name drug Celexa. In Australia, the UK, Germany, Portugal, Poland, and most European countries, it is licensed for depressive episodes and panic disorder with or without agoraphobia. In Spain, it is also used for obsessive-compulsive disorder.

Efficacy

The advantage of this drug is that it has no effect on cholinergic muscarinic receptors, histamine receptors and α-adrenergic receptors . Because if these receptors are inhibited,  a lot of side effects caused by antidepressants will produce, such as dry mouth, sedation, orthostatic hypotension. Citalopram hydrobromide is effective for not only endogenous depression patients but also non-endogenous depression patients. Its antidepressant effect is usually established after 2-4 weeks . Citalopram hydrobromide does not affect the cardiac conduction system and blood pressure, which is particularly important for elderly patients. In addition, citalopram hydrobromide does not affect the blood, liver and kidney systems. Rare side effects and the most mild sedative properties make it particularly suitable for long-term treatment.It does not lead to weight gaining,and it does not strengthen the role of alcohol.

Side effects

You should not use this medicine if you are allergic to citalopram or escitalopram (Lexapro), or if you also take pimozide.
Do not use citalopram if you have used an monoamine oxidase inhibitor (MAOI) in the past 14 days. A dangerous drug interaction could occur. MAOI inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Side effects are usually small, very mild and transient. The most common adverse reactions are: nausea, increased sweating, salivation reduction, headaches and sleep time shortening. They are usually more obvious in the first or second week when treatment begins, and they generally disappear with the improvement of depression. In rare cases ,seizures have been observed. For  patients who suffer bradycardia , bradycardia can make treatment more complicated.

References

http://www.rxlist.com/celexa-drug.htm
https://en.wikipedia.org/wiki/Citalopram
https://www.drugs.com/citalopram.html

Description

Citalopram (hydrobromide) (Item No. 23252) is an analytical reference material categorized as an antidepressant. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .

Chemical Properties

White or almost white, crystalline powder.

Originator

Celexa,Lundbeck, Forest

Uses

An inhibitor of serotonin (5-HT) uptake. Used as an antidepressant

Uses

Antidepressant;5HT uptake inhibitor

Uses

Anti-depressant/Anti-psychotic

Uses

Citalopram hydrobromide has been used:

  • to examine its effects on?sirt?mRNA and mammalian sirtuins (SIRT) expression in mice
  • to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats
  • for 5-hydroxytryptamine (5-HT) competition uptake assays

Manufacturing Process

5-Carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuranwas synthesized by three methods: 1. A solution of 1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3-dihydroisobenzofuran-5-yl magnesium bromide in dry THF (90 mL) (prepared by ordinary methods from 5-bromo-1-(4-fluorophenyl)-1-(3-
dimethylaminopropyl)-1,3-dihydro-isobenzofuran (9 g, 0.024 mole) and
magnesium (0.73 g, 0.03 mole)) was added to dry solid CO2 (50 g). After addition, the mixture was left at room temperature for 16 hours. The volatile materials were removed in vacuo and the residue was taken up in water (100 mL). pH was adjusted to 5.5 by adding HCl (aqueous, 4 N). The aqueous phase was extracted with toluene (100 mL). The toluene was removed in vacuo and the 5-carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran was obtained as oil. Yield 6 g.
2. To a solution of 5-bromo-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)- 1,3-dihydroisobenzofuran (9 g, 0.024 mole) in tertbutyl methyl ether (150 mL) was added n-BuLi (1.6 M in hexanes, 40 mL) at -78 to -65°C. The temperature of the solution was allowed to raise to -30°C over a period of 2 hours. The reaction mixture was added to dry solid CO2 (50 g). After addition, the mixture was left at room temperature for 16 hours. The volatile materials were removed in vacuo and the residue was taken up in water (100 mL). pH was adjusted to 5.5 by adding HCl (aqueous, 4 N). The aqueous phase was extracted with toluene (100 mL). The toluene was removed in vacuo and the 5-carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran was obtained as an oil. Yield 7.5 g.
3. n-BuLi (20 mL, 1.6 M in hexane) was added to a solution of isopropylmagnesium chloride (8.0 mL, 2 M in diethyl ether) in THF (25 mL) at 0°C. The resulting mixture was stirred at 0°C for 1 h, then cooled to -78°C and a solution of 5-bromo-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydro-isobenzofuran (5.0 g, 13.0 mmol) in THF (25 mL) was added. The mixture was allowed to warm to -10°C during 1 h, then cooled again to -78°C and CO2 (5.7 g, 130 mmol) was added. The mixture was allowed to warm to room temperature, and then evaporated. Ion exchange chromatography of the residue (Dowex RTM-50, acidic form) eluting with 1 M NH3 afforded the 5- carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran as a thick oil.
5-Carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran (5 g, 0.015 mole) and sulfamide (1.65 g, 0.017 mole) were dissolved in sulfolane (15 mL). Thionyl chloride (2.25 g, 0.019 mole) was added at room temperature and the temperature of the reaction mixture was raised to 130°C for 2 hours. The reaction mixture was allowed to cool to 75°C and water (25 mL) was added. The temperature was held at 75°C for 15 min, and then the reaction mixture was cooled to room temperature. pH was ajusted to 9 with ammonium hydroxide and then n-heptane (75 mL) was added. The temperature was raised to 70°C and the hot n-heptane layer was isolated from which the 5-cyano-1-(4-fluorophenyl)-1-(3- dimethylaminopropyl)-1,3-dihydroisobenzofuran (Citalopram, free base) crystallised on cooling. Yield 3.77 g. Purity (HPLC peak area) >97%. The hydrobromide was prepared in conventional manner and crystallized from isopropanol; melting point 148-150°C.

brand name

Celexa (Forest).

Therapeutic Function

Antidepressant

General Description

Citalopram is an antidepressant sold under the trade names Celexa? and Cipramil for the treatment of major depression. Citalopram is a selective serotonin reuptake inhibitor, a class of drugs that also includes fluoxetine, paroxetine, and sertraline. This Certified Snap-N-Spike? Solution is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.

Hazard

A poison.

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (Ki = 5.4 nM); antidepressant

storage

Room temperature

References

1) Mateo?et al.?(2000),?Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo;?Neuropharmacology?39?2036 2) Lekakis?et al.?(2010),?Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules; Int. J. Cardiol.?139?150 3) Cipriani?et al.?(2009),?Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis; Lancet?373?746 4) Naranjo?et al.?(1987),?The serotonin uptake inhibitor citalopram attenuates ethanol intake; Clin. Pharmacol. Ther.?41?266

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Preparation Products

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View Lastest Price from Citalopram hydrobromide manufacturers

Hebei Longbang Technology Co., Ltd
Product
Citalopram hydrobromide 59729-32-7
Price
US $6.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-06-03
Sinoway Industrial co., ltd.
Product
Citalopram hydrobromide 59729-32-7
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
98.5% up / EP
Supply Ability
20 tons
Release date
2024-06-27
hebei hongtan Biotechnology Co., Ltd
Product
Citalopram hydrobromide 59729-32-7
Price
US $80.00-60.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
1000
Release date
2024-05-13

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