I-SAP

Product Name: I-SAP
CAS No.: 133538-58-6
Chemical Name: I-SAP
Synonyms: I-SAP;I SAP,ISAP;THROMBOXANE A2;SZNMERGTFJHNSM-JAWYFFTGSA-N;IODOPHENYL SULFONYL AMINO PINANE;7-(6,6-dimethyl-3-(4-iodobenzenesulfonylamino)bicyclo(3.1.1.)hept-2-yl)-5-heptenoic acid;5-Heptenoic acid, 7-[(1S,2S,3S,5R)-3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-, (5Z)-;[3S-[1alpha,3beta-5alpha]]-7-[3-[[(4-Ifodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5Z-heptenoic acid;[3S-[1ALPHA,2ALPHA,3BETA-5ALPHA]]-7-[3-[[(4-IODOPHENYL)SULFONYL]AMINO]-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]-5Z-HEPTENOIC ACID
CBNumber: CB2736538
Molecular Formula: C22H30INO4S
Formula Weight: 531.45
MOL File: 133538-58-6.mol

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I-SAP Property

Boiling point:: 606.3±61.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: >50 mg/ml (from Pinane TXA2); DMSO: >25 mg/ml (from Pinane TXA2); Ethanol: >100 mg/ml (from Pinane TXA2); PBS pH 7.2: >100 μg/ml (from Pinane TXA2)
pka: 4.76±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19021
Product name: I-SAP
Purity: ≥98%
Packaging: 100μg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 19021
Product name: I-SAP
Purity: ≥98%
Packaging: 500μg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 19021
Product name: I-SAP
Purity: ≥98%
Packaging: 1mg
Price: $575
Updated: 2024/03/01

AK Scientific

Product number: 1803AH
Product name: I-SAP
Packaging: 1mg
Price: $737
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0290099
Product name: [3S-[1ALPHA,3BETA-5ALPHA]]-7-[3-[[(4-IODOPHENYL)SULFONYL]AMINO]-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]-5Z-HEPTENOIC ACID
Purity: 98.00%
Packaging: 1MG
Price: $1097.25
Updated: 2021/12/16

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I-SAP Chemical Properties,Usage,Production

Uses

I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].

IC 50

TXA₂ Receptor

References

[1] Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5(1):1-4. PMID:1419073
[2] Schr?r K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49(7):921-7. DOI:10.1016/0006-2952(95)00015-r

I-SAP Preparation Products And Raw materials

Raw materials

Preparation Products

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I-SAP Suppliers

China 29 Switzerland 1 United Kingdom 1 United States 3 Global 34

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Guangzhou Biopark Technology Co., Ltd.

Tel: 020-83808789
Country: CHINA
ProdList: 179
Advantage: 58

Chongqing Boer Biotechnology Co., Ltd.

Tel: 13251428727， 13368356747
Country: CHINA
ProdList: 157
Advantage: 58

133538-58-6, I-SAPRelated Search:

PINANE (1S)-(-)-CIS-PINAME 125I-SAP 4-iodobenzenesulfonamide N-N-OCTYL BENZENESULFONAMIDE (+)-ISOPINOCAMPHEYLAMINE 4,4-DIMETHYLCYCLOHEXYLAMINE 2,3-DIMETHYLCYCLOHEXYLAMINE I-SAP

THROMBOXANE A2

I-SAP

IODOPHENYL SULFONYL AMINO PINANE

[3S-[1ALPHA,2ALPHA,3BETA-5ALPHA]]-7-[3-[[(4-IODOPHENYL)SULFONYL]AMINO]-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]-5Z-HEPTENOIC ACID

[3S-[1alpha,3beta-5alpha]]-7-[3-[[(4-Ifodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5Z-heptenoic acid

7-(6,6-dimethyl-3-(4-iodobenzenesulfonylamino)bicyclo(3.1.1.)hept-2-yl)-5-heptenoic acid

SZNMERGTFJHNSM-JAWYFFTGSA-N

I SAP,ISAP

5-Heptenoic acid, 7-[(1S,2S,3S,5R)-3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-, (5Z)-

133538-58-6

C22H30INO4S