ChemicalBook > CAS DataBase List > 3,3',4',5,6,7-HEXAHYDROXYFLAVONE

3,3',4',5,6,7-HEXAHYDROXYFLAVONE

Product Name: 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
CAS No.: 90-18-6
Chemical Name: 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
Synonyms: QUERCETAGIN;QUERCETAGETIN;QUERCETAGENIN;6-Hydroxyquercetin;6,7,4'-Quercetagetin;QUEBRACHITOL, (-)-(RG);Quercetagetin 7-glucoside;Quercetagetin, 10 mM in DMSO;3,5,6,7,3',4'-HEXAHYDROXYFLAVONE;3,3',4',5,6,7-HEXAHYDROXYFLAVONE
CBNumber: CB2737863
Molecular Formula: C15H10O8
Formula Weight: 318.24
MOL File: 90-18-6.mol

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3,3',4',5,6,7-HEXAHYDROXYFLAVONE Property

Melting point:: >300°C
Boiling point:: 732.4±60.0 °C(Predicted)
Density: 1.912±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)
form: A crystalline solid
pka: 6.12±0.40(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
InChIKey: ZVOLCUVKHLEPEV-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=C(O)C(O)=C2C(=O)C=1O
LogP: 2.230 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL85766
Product name: Quercetagetin
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 5 mg
Price: $549
Updated: 2025/07/31

Sigma-Aldrich

Product number: 551590
Product name: Quercetagetin - CAS 90-18-6 - Calbiochem
Purity: A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC?? = 340 nM).
Packaging: 5MG
Price: $362
Updated: 2022/05/15

Cayman Chemical

Product number: 18645
Product name: Quercetagetin
Purity: ≥98%
Packaging: 500μg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18645
Product name: Quercetagetin
Purity: ≥98%
Packaging: 1mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 18645
Product name: Quercetagetin
Purity: ≥98%
Packaging: 5mg
Price: $324
Updated: 2024/03/01

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3,3',4',5,6,7-HEXAHYDROXYFLAVONE Chemical Properties,Usage,Production

Uses

Quercetagetin (6-Hydroxyquercetin) is a flavonoid[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties.

Definition

ChEBI: A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.

Biological Activity

Cell permeable: yes', 'Primary Target
PIM1 kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 340 nM against PIM1 kinase

in vivo

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively^[3].

Animal Model:	SKH-1 hairless mice model^[3]
Dosage:	4 or 20 nmol
Administration:	Topical application; 28 weeks
Result:	Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.

IC 50

PIM1: 0.34 μM (IC₅₀); PIM2: 3.45 μM (IC₅₀); RSK2: 2.82 μM (IC₅₀); PKA: 21.2 μM (IC₅₀)

References

[1] Yang X, et al. Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J Sci Food Agric. 2011 Aug 15;91(10):1925-7. DOI:10.1002/jsfa.4402
[2] Holder S, et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. 2007 Jan;6(1):163-72. DOI:10.1158/1535-7163.MCT-06-0397
[3] Baek S, et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23. DOI:10.1016/j.jmb.2012.10.019

3,3',4',5,6,7-HEXAHYDROXYFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,3',4',5,6,7-HEXAHYDROXYFLAVONE manufacturers

Career Henan Chemical Co

Product: 3,3',4',5,6,7-HEXAHYDROXYFLAVONE 90-18-6
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

90-18-6, 3,3',4',5,6,7-HEXAHYDROXYFLAVONERelated Search:

Quercetin 3-O-neohesperidoside Naringenin Quercetin-3-O-b-D-glucose-7-O-b-D-gentiobiosiden QUERCETIN-3-O-GLUCURONIDE quercetin 3-sambubioside Quercitrin Quercetagetin-7-O-glucoside ARTEMETIN 3',4',5',3,5,7-HEXAHYDROXYFLAVONE,3,5,7,3',4',5'-HEXAHYDROXYFLAVONE,3,3μ,4μ,5,5μ,7-Hexahydroxyflavone, Cannabiscetin,3,3',4',5,5',7-HEXAHYDROXYFLAVONE 3,3&#39,4&#39,5,7,8-Hexahydroxyflavone,3,3',4',5,7,8-HEXAHYDROXYFLAVONE 8-GLUCOSIDE CASTICIN 3,3',4',5,6,7-HEXAHYDROXYFLAVONE centaureidin 3,3',4',5,6,7,8-heptamethoxyflavone 5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone 3,5,7,3',4',8-HEXAHYDROXYFLAVONE,3,5,7,8,3',4'-HEXAHYDROXYFLAVONE,3,5,7,8,3&#39,4&#39-Hexahydroxyflavone,3,3',4',5,7,8-Hexahydroxyflavone 3',4',5,6,7,8-Hexahydroxyflavone centaurein

QuercetagitrinQuercetagetin 7-glucoside

QUERCETAGIN

QUERCETAGENIN

QUERCETAGETIN

3,3',4',5,6,7-HEXAHYDROXYFLAVONE

3,5,6,7,3',4'-HEXAHYDROXYFLAVONE

2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone

2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one

3,5,6,7-Tetrahydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one

6,7,4'-Quercetagetin

6-Hydroxyquercetin

QUEBRACHITOL, (-)-(RG)

Quercetagetin 7-glucoside

2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-1-benzopyran-4-one

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-

2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-chromen-4-one

Quercetagetin, 10 mM in DMSO

90-18-6

Flavanols