KN-93

ChemicalBook > CAS DataBase List > KN-93

Product Name: KN-93
CAS No.: 139298-40-1
Chemical Name: KN-93
Synonyms: KN-93;KN KN;CS-1099;KN-93,98%;KN-93-H3PO4;KN-93(free base);KN-93;KN 93;KN93;KN 93 (Z/E form);InSolution? KN-93;KN-93 base or HCI
CBNumber: CB2751988
Molecular Formula: C26H29ClN2O4S
Formula Weight: 501.04
MOL File: 139298-40-1.mol

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KN-93 Property

Density: 1.288
storage temp.: 2-8°C
solubility: DMSO: 1 mg/mL
form: Off-white solid
color: white
biological source: synthetic (organic)
Water Solubility: water: 5mg/mL
InChIKey: LLLQTDSSHZREGW-AATRIKPKSA-N
CAS DataBase Reference: 139298-40-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 22-24/25-36/37
WGK Germany: 3
HS Code: 29299000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: K1385
Product name: KN-93
Purity: ≥98% (HPLC)
Packaging: 0.1mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: K1385
Product name: KN-93
Purity: ≥98% (HPLC)
Packaging: 0.5mg
Price: $388
Updated: 2024/03/01

Sigma-Aldrich

Product number: 422708
Product name: KN-93
Packaging: 1mg
Price: $181
Updated: 2023/06/20

Sigma-Aldrich

Product number: 422708
Product name: KN-93
Packaging: 5mg
Price: $586
Updated: 2023/06/20

TCI Chemical

Product number: K0055
Product name: KN-93
Purity: >98.0%(HPLC)
Packaging: 5mg
Price: $135
Updated: 2024/03/01

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KN-93 Chemical Properties,Usage,Production

Description

KN-93 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (K_i = 370 nM). It does not affect the activities of PKA, PKC, MLCK, or Ca²⁺-phosphodiesterase. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC₅₀ = 300 nM). More recently, KN-93 has been used to implicate roles for CaMKII in Ca²⁺-induced Ca²⁺ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca²⁺-dependent activation of HIF-1α in colon cancer cells.

Chemical Properties

white to off-white powder

Uses

KN-93 has been used:

as an inhibitor to block αCaMKII (Ca²⁺/calmodulin-dependent protein kinase IIα)
as CaMKII inhibitor to pre-treat hippocampal slices
to treat the cells, to alter the cytoskeleton (CSK) structure and function during the experiment

Uses

A potent and selective inhibitor of Ca2+/Calmoduline-dependent protein kinase II (CaMKII).

Definition

ChEBI: A sulfonamide resulting from the formal condensation of p-methoxybenzenesulfonic acid with the anilino nitrogen of 2-(aminomethyl)-N-(2-hydroxyethyl)aniline in which the hydrogens of the primary amino group have been replace by methyl and p-chlorocinnamyl groups. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.

General Description

Cell-permeable, reversible, and competitive inhibitor of rat brain Ca⁺²/calmodulin-dependent protein kinase II (K_i = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

Biological Activity

Potent inhibitor of CaM kinase II (IC 50 = 0.37 μ M). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC 50 = 307 nM for Kv1.5); independent of CaM kinase II inhibition.

Biochem/physiol Actions

KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step.

storage

Store at +4°C

KN-93 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from KN-93 manufacturers

Career Henan Chemica Co

Product: KN-93 139298-40-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98%HPLC/LC
Supply Ability: g/kg/tons
Release date: 2020-11-02

139298-40-1, KN-93Related Search:

N-Methylaniline 2-Methylaminoethanol N-Methyl pyrrole N-Methylbenzamide N-Methyldiethanolamine KN-93 in Solution KN-93 P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE 4-HYDROXY-N-PHENYLBENZENE SULPHONAMIDE

2-[N-(2-HYDROXYETHYL)-N-(4-METHOXYBENZENESULFONYL)]AMINO-N-(4-CHLOROCINNAMYL)-N-METHYLBENZYLAMINE

METHOXYBENZENE-SULFONAMIDE

KN-93

KN-93, WATER-SOLUBLE

N-[2-[[[3-(4'-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4'-METHOXY-BENZENESULFONAMIDE PHOSPHATE

N-[2-[[[3-(4-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULPHONAMIDE

N-[2-N-4-CHLOROCINNAMYL-N-METHYLAMINOMETHYLPHENYL]-N-[2-HYDROXYETHYL]-4-METHOXYBENZENESULFONAMIDE

KN-93,98%

KN-932-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine

N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

n-[2-[[[3-(4'-chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-n-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide phosphate salt

N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]MethylaMino]Methyl]phenyl]-N-(2-hydroxyethyl)-4-MethoxybenzenesulfonaMide

KN-93(free base)

KN-93 - CAS 139298-40-1 - Calbiochem

InSolution KN-93 - CAS 139298-40-1 - Calbiochem

CS-1099

N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULFONAMIDE

KN-93;KN 93;KN93

KN-93-H3PO4

KN 93 N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxyb

InSolution? KN-93

KN-93 base or HCI

KN KN

N-?[2-?({[(2E)?-?3-?(4-?CHLOROPHENYL)?PROP-?2-?EN-?1-?YL]?(METHYL)?AMINO}?METHYL)?PHENYL]?-?2-?HYDROXY-?S-?(4-?METHOXYPHENYL)?ETHANESULFONAMIDO

Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-

N-[2-[[[3-(4-Chlorophenyl)allyl](methyl)amino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

Inhibitor,Calmodulin-dependent protein kinases,Autophagy,KN-93,KN 93,KN93,Calmodulin-dependent kinases,inhibit,CaMK

KN 93 (Z/E form)

KN-93, CaM kinase II inhibitor

KN-93, 10 mM in DMSO

139298-40-1

C26H29ClN2O4S

Kinase/Phosphatase Biology

Serine/Threonine Kinase Inhibitors

Cell Signaling and Neuroscience

Calcium/Calmodulin-Dependent Protein Kinase (CaMK)

Cell Biology

BioChemical

Inhibitors

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Protein Kinase