CETABEN Property

Boiling point:

503.4±33.0 °C(Predicted)

Density 

0.979±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide

form 

crystalline solid

pka

4.76±0.10(Predicted)

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

CETABEN Chemical Properties,Usage,Production

Uses

Antihyperlipoproteinemic.

Biological Activity

cetaben is an unique pparα-independent peroxisome proliferator.the fibrate class of hypolipidemic drugs, such as fenofibrate and clofibrate, elicit their effects via binding to and activating peroxisome proliferator-activated receptor α (pparα).

in vitro

previous study showed that cetaben could cause little but reversible proliferation and morphological heterogeneity with the occurrence of dumbbell- and cup-shaped peroxisomal profiles. peroxisomes in hepg2 cells showed marked variation in size and shape. cetaben treatment of hepg2 cells was able to lead to disintegration of golgi regions and augmented mitochondrial matrix [1].

in vivo

animal study found that the changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of both cetaben and clofibric acid 200 mg/kg/day to male wistar rats. no analogical changes were observed after cetaben treatment in the livers of experimental animals. it was also found that both drugs could increase the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase--enzymes with proven mitochondrial and peroxisomal location. contrary to clofibric acid, cetaben did not increase solubilization of peroxisomal enzymes [2].

References

[1] kovacs, w. ,walter, i., and stangl, h. cetaben-induced changes on the morphology and peroxisomal enzymes in mh1c1 rat hepatoma and hepg2 human hepatoblastoma cells. histochemistry and cell biology 115, 509-519 (2001).
[2] chandoga, j. ,hampl, l.,turecky, l., et al. cetaben is an exceptional type of peroxisome proliferator. international journal of biochemistry 26(5), 679-696 (1994).