2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE

Product Name: 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE
CAS No.: 80957-68-2
Chemical Name: 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE
Synonyms: 5,6,7,8-Tetrahydro-1,6phthyridine;5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE;1,6-Naphthyridine, 5,6,7,8-tetrahydro-;5,6,7,8-tetrahydro-1,6-naphthyridine HCl Salt;5,6,7,8-tetrahydro-1,6-naphthyridine(SALTDATA: 2HCl 0.5H2O)
CBNumber: CB2755906
Molecular Formula: C8H10N2
Formula Weight: 134.18
MOL File: 80957-68-2.mol

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2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Property

Boiling point:: 247.6±30.0 °C(Predicted)
Density: 1.068±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 7.95±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T295703
Product name: 5,6,7,8-Tetrahydro-1,6-naphthyridine
Packaging: 250mg
Price: $425
Updated: 2021/12/16

Matrix Scientific

Product number: 073167
Product name: 5,6,7,8-Tetrahydro-1,6-naphthyridine
Purity: 95+%
Packaging: 250mg
Price: $615
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0072675
Product name: 5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE
Purity: 95.00%
Packaging: 500MG
Price: $697.2
Updated: 2021/12/16

Matrix Scientific

Product number: 073167
Product name: 5,6,7,8-Tetrahydro-1,6-naphthyridine
Purity: 95+%
Packaging: 1g
Price: $1281
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0072675
Product name: 5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $1318.24
Updated: 2021/12/16

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2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Chemical Properties,Usage,Production

Uses

5,6,7,8-Tetrahydro-1,6-naphthyridine is used in the synthetic preparation of quinolizidinone carboxylic acid selective M1 allosteric modulators.

Synthesis

75510-02-0

80957-68-2

6-Benzyl-5,6,7,8-tetrahydro-1,6-naphthyridine (3.9 g, 17.4 mmol) was used as a starting material and dissolved in 60 mL of acetic acid. A 0.4 g palladium/carbon catalyst was added. The reaction solution was transferred to a hydrogen reaction vessel and after three displacements with hydrogen, the reaction was carried out at 50 °C for 48 hours. After completion of the reaction, the catalyst was removed by filtration. The solvent was removed by distillation under reduced pressure and the resulting crude product was purified by column chromatography using a solvent mixture of dichloromethane and methanol (5:1, v/v) to afford the target product 5,6,7,8-tetrahydro-1,6-naphthyridine (1.48 g, 64% yield).

References

[1] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 7, p. 2522 - 2529
[2] Patent: CN108250128, 2018, A. Location in patent: Paragraph 0638; 0640; 0643; 0644
[3] Patent: WO2009/56556, 2009, A1. Location in patent: Page/Page column 41
[4] Journal of Medicinal Chemistry, 2004, vol. 47, # 21, p. 5167 - 5182

2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Suppliers

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View Lastest Price from 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE manufacturers

Career Henan Chemical Co

Product: 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE 80957-68-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2019-08-29

80957-68-2, 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINERelated Search:

2-Chloro-6-(trifluoromethyl)nicotinonitrile 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro- 5-chloro-1,2,3,4-tetrahydro-1,6-naphthyridine 5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDIN-3-OL 6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one 5,6,7,8-TETRAHYDRO-6-(PHEHYLMETHYL)-1,6-NAPHTHYRIDIN-3-AMINE 5-Bromo-1,2,3,4-tetrahydro-[1,7]naphthyridine METHYL 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE 3-BROMO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE 5,6,7,8-tetrahydro-2,6-naphthyridin-1-amine 3-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine 5,6,7,8-tetrahydro-2,6-naphthyridin-1(2H)-one hydrochloride Pyrido[2,3-b][1,6]naphthyridine, 6,7,8,9-tetrahydro- (9CI) 4-(3,4-DIHYDROPYRIDO[4,3-B]-1,6-NAPHTHYRIDIN-2(1H)-YL)-4-OXOBUTANOICACID 1,2,3,4-TETRAHYDROPYRIDO[4,3-B]-[1,6]-NAPHTHYRIDINE AKOS USSH-4110802 2-BENZYL-1,2,3,4-TETRAHYDROPYRIDO[4,3-B][1,6]NAPHTHYRIDINE Pyrido[2,3-b][1,6]naphthyridine, 7-acetyl-6,7,8,9-tetrahydro- (9CI)

5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE

1,6-Naphthyridine, 5,6,7,8-tetrahydro-

5,6,7,8-tetrahydro-1,6-naphthyridine(SALTDATA: 2HCl 0.5H2O)

5,6,7,8-tetrahydro-1,6-naphthyridine HCl Salt

5,6,7,8-Tetrahydro-1,6phthyridine

80957-68-2

Heterocycle-Pyridine series

CHIRAL CHEMICALS