ChemicalBook > CAS DataBase List > 12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE

Product Name
12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE
CAS No.
206052-03-1
Chemical Name
12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE
Synonyms
DDMS;DIBROMO-DODECENYL-METHYLSULFIMIDE;DDMS (Dibromo-dodecenyl-methylsulfimide);12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE;11-Dodecenamide, 12,12-dibromo-N-(methylsulfonyl)-
CBNumber
CB2756877
Molecular Formula
C13H23Br2NO3S
Formula Weight
433.2
MOL File
206052-03-1.mol
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12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Property

Density 
1.494±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤20mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
solution in ethanol.
pka
4.68±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10018
Product name
DDMS
Purity
≥98%
Packaging
1mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
10018
Product name
DDMS
Purity
≥98%
Packaging
5mg
Price
$308
Updated
2024/03/01
Cayman Chemical
Product number
10018
Product name
DDMS
Purity
≥98%
Packaging
10mg
Price
$545
Updated
2024/03/01
TRC
Product number
D195300
Product name
DDMS
Packaging
5mg
Price
$210
Updated
2021/12/16
TRC
Product number
D195300
Product name
DDMS
Packaging
25mg
Price
$895
Updated
2021/12/16
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12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Chemical Properties,Usage,Production

Uses

DDMS is used as an irreversible inhibitor that has selectivity for the CYP4A2 enzyme which synthesizes 20-HETE in the mammalian kidney. 20-HETE plays an important role in vascular homeostasis.

Biological Activity

ddms is a cyp4a2 enzyme inhibitor.biosynthesis of 20-hete from arachidonic acid by the cytochrome p450 4a (cyp450 4a) isoforms is a key component of vascular homeostasis, especially in renal circulation.

in vitro

to determine whether inhibition of 20-hete contributes to the vasodilatory effects of no, the effects of ddms on the response to snp were examined in rat renal arterioles preconstricted with phenylephrine). results showed that after ddms treatment, snp could increase vascular diameter by only 17% [1].

in vivo

the effects of ddms on the mean arterial pressure and renal blood flow responses to infusion of an no donor and a synthase inhibitor were also examined. it was found that infusion of mahma nonoate at 1, 3, 5, and 10 nmol/min was able to reduce mean arterial pressure by 16, 30, 40, and 48 mm hg and lowered renal vascular resistance by 15 %, 26 %, 30%, and 34% of control. in addition, after ddms treatment at 10 mg/kg, the mean arterial pressure and renal vascular resistance responsed to 1-hexamine, 6-(2-hydroxy-1-methyl-2-nitrohydrazino)n-methyl averaged only 20% of those seen during control [1].

References

[1] alonso-galicia, m. ,drummond, h.a.,reddy, k.k., et al. inhibition of 20-hete production contributes to the vascular responses to nitric oxide. hypertension 29, 320-325 (1997).

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Suppliers

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206052-03-1, 12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDERelated Search:


  • 12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE
  • DDMS
  • DIBROMO-DODECENYL-METHYLSULFIMIDE
  • 11-Dodecenamide, 12,12-dibromo-N-(methylsulfonyl)-
  • DDMS (Dibromo-dodecenyl-methylsulfimide)
  • 206052-03-1
  • C13H23Br2NO3S