ChemicalBook > CAS DataBase List > 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE

5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE

Product Name: 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE
CAS No.: 374930-88-8
Chemical Name: 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE
Synonyms: 1-Boc-4-(5-bromopyrimidin-2-yl)piperazine;1-Boc-4-(5-bromopyri;5-Bromo-2-(4-Boc-1-piperazinyl)pyrimidine;5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE;5-Bromo-2-[(N-Boc)piperazin-1-yl]pyrimidine;1-N-Boc-4-(5-broMopyriMidin-2-yl)piperazine;4-(5-bromo-2-pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester;4-(5-BROMOPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(5-BROMOPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;1-Piperazinecarboxylic acid, 4-(5-bromo-2-pyrimidinyl)-, 1,1-dimethylethyl ester
CBNumber: CB2759555
Molecular Formula: C13H19BrN4O2
Formula Weight: 343.22
MOL File: 374930-88-8.mol

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5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE Property

Boiling point:: 451.0±55.0 °C(Predicted)
Density: 1.414±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 3.46±0.42(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C13H19BrN4O2/c1-13(2,3)20-12(19)18-6-4-17(5-7-18)11-15-8-10(14)9-16-11/h8-9H,4-7H2,1-3H3
InChIKey: UKCBGXCNXOKVTF-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=NC=C(Br)C=N2)CC1

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BML00305
Product name: 5-Bromo-2-(4-boc-piperazin-1-yl)pyrimidine
Purity: Aldrich
Packaging: 1g
Price: $68.1
Updated: 2023/01/07

TRC

Product number: B680035
Product name: 5-Bromo-2-(4-BOC-piperazin-1-yl)pyrimidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B680035
Product name: 5-Bromo-2-(4-BOC-piperazin-1-yl)pyrimidine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B680035
Product name: 5-Bromo-2-(4-BOC-piperazin-1-yl)pyrimidine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR8545
Product name: tert-Butyl4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate
Packaging: 1g
Price: $70
Updated: 2021/12/16

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5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

32779-36-5

57260-71-6

374930-88-8

To 1,4-dioxane (30 mL) was added N-BOC-piperazine (2.89 g, 15.51 mmol), 5-bromo-2-chloropyrimidine (2.00 g, 10.34 mmol) and potassium carbonate (2.86 g, 20.68 mmol). The reaction mixture was heated to 110 °C and stirred for 12 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered to remove insoluble material and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (20:1, v/v) to afford tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate as a light yellow solid (3.15 g, 88.7% yield). Mass spectrum (ESI, positive ion mode) m/z: 343.1 [M + H]+. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.29 (s, 2H), 3.83-3.66 (m, 4H), 3.56-3.41 (m, 4H), 1.48 (s, 9H).

References

[1] Patent: WO2016/192657, 2016, A1. Location in patent: Page/Page column 50
[2] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 54; 55
[3] Patent: WO2016/20307, 2016, A1. Location in patent: Page/Page column 44
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
[5] Patent: WO2017/144633, 2017, A1. Location in patent: Page/Page column 109

5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE 374930-88-8
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

374930-88-8, 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINERelated Search:

tert-butyl 4-(5-iodopyrimidin-2-yl)piperazine-1-carboxylate tert-Butyl 4-(4-bromopyridin-2-yl)piperazine-1-carboxylate 5-BROMO-2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)BENZENE-1,4-DIAMINE

5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE

4-(5-BROMOPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%

5-Bromo-2-[(N-Boc)piperazin-1-yl]pyrimidine

1-Boc-4-(5-bromopyrimidin-2-yl)piperazine

1-Piperazinecarboxylic acid, 4-(5-bromo-2-pyrimidinyl)-, 1,1-dimethylethyl ester

1-Boc-4-(5-bromopyri

5-Bromo-2-(4-Boc-1-piperazinyl)pyrimidine

4-(5-BROMOPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-N-Boc-4-(5-broMopyriMidin-2-yl)piperazine

4-(5-bromo-2-pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester

374930-88-8

pharmacetical

Organohalides

Pyrimidine