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2-Chloro-5-(chloromethyl)pyridine

Description Structure Sources
Product Name
2-Chloro-5-(chloromethyl)pyridine
CAS No.
70258-18-3
Chemical Name
2-Chloro-5-(chloromethyl)pyridine
Synonyms
2-chloro-chloromethylpyridine;Pyridine, 2-chloro-5-(chloromethyl)-;6-Chlo;60% in DMF;AKOS MSC-0759;AURORA KA-6694;2-Chloro-5-(ch;TIMTEC-BB SBB003948;2-Chloro-5-Chloro-Me;imidacloprid impurity
CBNumber
CB2761158
Molecular Formula
C6H5Cl2N
Formula Weight
162.02
MOL File
70258-18-3.mol
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2-Chloro-5-(chloromethyl)pyridine Property

Melting point:
37-42 °C(lit.)
Boiling point:
267.08°C (rough estimate)
Density 
1.4411 (rough estimate)
refractive index 
1.6000 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-0.75±0.10(Predicted)
form 
Moist Crystals
color 
Beige
Water Solubility 
Insoluble in water.
BRN 
1635690
InChI
InChI=1S/C6H5Cl2N/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3H2
InChIKey
SKCNYHLTRZIINA-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(CCl)C=C1
CAS DataBase Reference
70258-18-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi,F
Risk Statements 
22-34-36-10
Safety Statements 
26-36/37/39-45-25-36-16
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive/Harmful
HazardClass 
LACHRYMATOR, CORROSIVE
HazardClass 
8
PackingGroup 
II
HS Code 
29333999
Storage Class
8A - Combustible corrosive hazardous materials
Hazard Classifications
Acute Tox. 4 Oral
Skin Corr. 1B
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
516910
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
97%
Packaging
5g
Price
$50.6
Updated
2025/07/31
Sigma-Aldrich
Product number
516910
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
97%
Packaging
25g
Price
$101
Updated
2025/07/31
TCI Chemical
Product number
C1628
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$303
Updated
2025/07/31
TCI Chemical
Product number
C1628
Product name
2-Chloro-5-(chloromethyl)pyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$895
Updated
2025/07/31
TRC
Product number
C364715
Product name
2-Chloro-5-(chloromethyl)pyridine
Packaging
25g
Price
$110
Updated
2021/12/16
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2-Chloro-5-(chloromethyl)pyridine Chemical Properties,Usage,Production

Description

2-Chloro-5-chloromethylpyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds1, having insecticidal activity. It is the raw material of pesticide products such as imidacloprid, acetamiprid as well as bactericide and herbicide2,3.

Structure

2-Chloro-5-(chloromethyl)pyridine, C6H5Cl2N, is almost planar, with an r.m.s. deviation of 0.0146 Å for all atoms except for the 5-choloromethyl Cl atom. The offset Cl atom lies above this plane with a Cl—C—C angle of 111.11 (17)°. In the crystal, mol­ecules are connected via inter­molecular C—H⋯N hydrogen bonds, forming dimers. The crystals were obtained by dissolving 2-Chloro-5-(chloromethyl)pyridine (0.2 g, 1.2 mmol) in ethanol (25 ml) and evaporating the solvent slowly at room temperature for about 5 d[1].

Sources

  1. https://www.alfa.com/en/catalog/L19284/
  2. https://www.trc-canada.com/product-detail/?C364715
  3. www.szqhbio.com/wap_news_detailen/id/1.htm

Chemical Properties

beige moist crystals

Uses

2-Chloro-5-(chloromethyl)pyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds.

Synthesis

150807-86-6

70258-18-3

General procedure for the synthesis of 2-chloro-5-chloromethylpyridine from the compound (CAS:150807-86-6): 18 g (0.1 mol) of 2-chloro-2-chloromethyl-4-cyano-butanal was dissolved in 50 ml of toluene, and 33 g (1.1 eq.) of solid phosgene was added to the toluene solution. The reaction mixture was stirred at 50°C for 5 hours. Upon completion of the reaction, the mixture was cooled to facilitate crystallization to afford the acetamiprid intermediate 2-chloro-5-chloromethylpyridine in 97% yield. Subsequently, the acetamiprid prodrug was further synthesized in 95% yield through methylation and esterification reaction steps.

References

[1] Zhi-Qiang Feng. “2-Chloro-5-(chloro-meth-yl)pyridine.” Acta crystallographica. Section E, Structure reports online 67 Pt 2 (2011): o366.

2-Chloro-5-(chloromethyl)pyridine Preparation Products And Raw materials

Raw materials

Nicotinic acid 3-(Chloromethyl)pyridine 2-Chloro-5-trichloromethylpyridine Phosphorus pentoxide 2-Chloro-5-methylpyridine 1,3-Cyclopentadiene

Preparation Products

Acetamiprid
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2-Chloro-5-(chloromethyl)pyridine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 471 Europe 4 France 1 Germany 8 India 22 Ireland 1 Japan 4 Jordan 1 South Korea 1 Switzerland 3 The Netherlands 1 Ukraine 3 United Kingdom 19 United States 57 Global 601
Jinan Junhe Pharmaceutical Co., Ltd
Tel
18653300596
Email
3989432235@qq.com
Country
China
ProdList
334
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58
Nanjing Bermuda Biotechnology Co., Ltd.
Tel
173-40521416 17340521416
Fax
17340521416
Email
1757224788@qq.com
Country
China
ProdList
1993
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58
Suzhou Senfeida Chemical Material Co., Ltd.
Tel
512-66387919 13862111431
Fax
0512-66387035
Email
sales2@senfeida.com
Country
China
ProdList
296
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58
Yangzhou juhechang Technology Co., Ltd
Tel
0514-0514-83662002 13073488988
Fax
0514-83662002
Email
13073488988@163.com
Country
China
ProdList
40
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
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56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
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View Lastest Price from 2-Chloro-5-(chloromethyl)pyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-5-chloromethylpyridine 70258-18-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-02
Jinan Finer Chemical Co., Ltd
Product
2-Chloro-5-chloromethylpyridine 70258-18-3
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000mt/year
Release date
2022-09-28
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Chloro-5-chloromethylpyridine 70258-18-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-24

70258-18-3, 2-Chloro-5-(chloromethyl)pyridineRelated Search:

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  • BENZYL HALIDE
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • Building Blocks
  • Pharmaceutical intermediates
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • Methyl Halides
  • Heterocycle-Pyridine series
  • API Intermediate
  • Pyridine series
  • Methyl Halides
  • HALOMETYL
  • Pyridine
  • 70258-18-3