2-Chloro-5-(chloromethyl)pyridine

Description Structure Sources

Product Name: 2-Chloro-5-(chloromethyl)pyridine
CAS No.: 70258-18-3
Chemical Name: 2-Chloro-5-(chloromethyl)pyridine
Synonyms: 2-chloro-chloromethylpyridine;Pyridine, 2-chloro-5-(chloromethyl)-;6-Chlo;60% in DMF;AKOS MSC-0759;AURORA KA-6694;2-Chloro-5-(ch;TIMTEC-BB SBB003948;2-Chloro-5-Chloro-Me;imidacloprid impurity
CBNumber: CB2761158
Molecular Formula: C6H5Cl2N
Formula Weight: 162.02
MOL File: 70258-18-3.mol

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2-Chloro-5-(chloromethyl)pyridine Property

Melting point:: 37-42 °C(lit.)
Boiling point:: 267.08°C (rough estimate)
Density: 1.4411 (rough estimate)
refractive index: 1.6000 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: -0.75±0.10(Predicted)
form: Moist Crystals
color: Beige
Water Solubility: Insoluble in water.
BRN: 1635690
InChI: InChI=1S/C6H5Cl2N/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3H2
InChIKey: SKCNYHLTRZIINA-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(CCl)C=C1
CAS DataBase Reference: 70258-18-3(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi,F
Risk Statements: 22-34-36-10
Safety Statements: 26-36/37/39-45-25-36-16
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive/Harmful
HazardClass: LACHRYMATOR, CORROSIVE
HazardClass: 8
PackingGroup: II
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 516910
Product name: 2-Chloro-5-(chloromethyl)pyridine
Purity: 97%
Packaging: 5g
Price: $49.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 516910
Product name: 2-Chloro-5-(chloromethyl)pyridine
Purity: 97%
Packaging: 25g
Price: $59.04
Updated: 2024/03/01

TCI Chemical

Product number: C1628
Product name: 2-Chloro-5-(chloromethyl)pyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $156
Updated: 2024/03/01

TCI Chemical

Product number: C1628
Product name: 2-Chloro-5-(chloromethyl)pyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $460
Updated: 2024/03/01

Alfa Aesar

Product number: L19284
Product name: 2-Chloro-5-(chloromethyl)pyridine, 96%
Packaging: 5g
Price: $41.65
Updated: 2024/03/01

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2-Chloro-5-(chloromethyl)pyridine Chemical Properties,Usage,Production

Description

2-Chloro-5-chloromethylpyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds¹, having insecticidal activity. It is the raw material of pesticide products such as imidacloprid, acetamiprid as well as bactericide and herbicide^2,3.

Structure

2-Chloro-5-(chloromethyl)pyridine, C6H5Cl2N, is almost planar, with an r.m.s. deviation of 0.0146 Å for all atoms except for the 5-choloromethyl Cl atom. The offset Cl atom lies above this plane with a Cl—C—C angle of 111.11 (17)°. In the crystal, molecules are connected via intermolecular C—H⋯N hydrogen bonds, forming dimers. The crystals were obtained by dissolving 2-Chloro-5-(chloromethyl)pyridine (0.2 g, 1.2 mmol) in ethanol (25 ml) and evaporating the solvent slowly at room temperature for about 5 d[1].

Sources

https://www.alfa.com/en/catalog/L19284/
https://www.trc-canada.com/product-detail/?C364715
www.szqhbio.com/wap_news_detailen/id/1.htm

Chemical Properties

beige moist crystals

Uses

2-Chloro-5-(chloromethyl)pyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds.

References

[1] Zhi-Qiang Feng. “2-Chloro-5-(chloro-meth-yl)pyridine.” Acta crystallographica. Section E, Structure reports online 67 Pt 2 (2011): o366.

2-Chloro-5-(chloromethyl)pyridine Preparation Products And Raw materials

Raw materials

Nicotinic acid 3-(Chloromethyl)pyridine 2-Chloro-5-trichloromethylpyridine Phosphorus pentoxide 2-Chloro-5-methylpyridine 1,3-Cyclopentadiene

Preparation Products

Acetamiprid

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2-Chloro-5-(chloromethyl)pyridine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 455 Europe 4 France 1 Germany 8 India 21 Ireland 1 Japan 4 Jordan 1 South Korea 1 Switzerland 3 The Netherlands 1 Ukraine 3 United Kingdom 19 United States 57 Global 584

Jinan Junhe Pharmaceutical Co., Ltd

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Nanjing Bermuda Biotechnology Co., Ltd.

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Jinan Junhe Pharmaceutical Co., Ltd

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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
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TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
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View Lastest Price from 2-Chloro-5-(chloromethyl)pyridine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2-Chloro-5-chloromethylpyridine 70258-18-3
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-04-24

Jinan Finer Chemical Co., Ltd

Product: 2-Chloro-5-chloromethylpyridine 70258-18-3
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000mt/year
Release date: 2022-09-28

hebei hongtan Biotechnology Co., Ltd

Product: 2-Chloro-5-chloromethylpyridine 70258-18-3
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-05-16

70258-18-3, 2-Chloro-5-(chloromethyl)pyridineRelated Search:

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70258-18-3

0258-18-3

BENZYL HALIDE

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines

Chloropyridines

Halopyridines

Building Blocks

Pharmaceutical intermediates

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Chloropyridines

Halopyridines

Methyl Halides

Heterocycle-Pyridine series

API Intermediate

Pyridine series

Methyl Halides

HALOMETYL

Pyridine

70258-18-3