4,4'-OXYBIS(PHENYL ISOCYANATE) Property

Melting point:

64-68 °C(lit.)

Boiling point:

196 °C5 mm Hg(lit.)

Density 

1.2700 (rough estimate)

refractive index 

1.5910 (estimate)

solubility 

Acetonitrile (Soluble)

form 

Solid

color 

White to Off-White

Stability:

Moisture Sensitive

CAS DataBase Reference

4128-73-8

EPA Substance Registry System

4,4'-Diisocyanatodiphenyl ether (4128-73-8)

Safety

Hazard Codes 

Xn,T+

Risk Statements 

20/21/22-36/37/38-42/43-26-25-21

Safety Statements 

23-26-36/37/39-45-36/37-28-22

RIDADR 

UN 2206 6.1/PG 3

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H330Fatal if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

4,4'-OXYBIS(PHENYL ISOCYANATE) Chemical Properties,Usage,Production

Chemical Properties

WHITE CRYSTALLINE SOLID

Uses

4,4'-Bis(isocyanatophenyl)oxide is a reagent used in the synthesis of lipid-conjugated Smac analogs with antitumor activity against human breast cancer cell lines.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.

Reactivity Profile

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.