5-Fluoropyrimidine-4,6-diol
- Product Name
- 5-Fluoropyrimidine-4,6-diol
- CAS No.
- 106615-61-6
- Chemical Name
- 5-Fluoropyrimidine-4,6-diol
- Synonyms
- 5-FLUORO-PYRIMIDINE-4,6-DIOL;4,6-Dihydroxy-5-fluoropyrimidine;5-Fluoro-4,6-dihydroxypyrimidine;5-Fluoro-6-hydroxy-4(3H)-pyrimidinone;5-fluoro-4-hydroxy-1H-pyrimidin-6-one;5-fluoro-6-hydroxypyriMidin-4(3H)-one;4(3H)-PyriMidinone, 5-fluoro-6-hydroxy-;4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy- (9CI);5-fluoro-6-hydroxy-3,4-dihydropyrimidin-4-one;5-FLUORO-PYRIMIDINE-4,6-DIOL ISO 9001：2015 REACH
- CBNumber
- CB2793070
- Molecular Formula
- C4H3FN2O2
- Formula Weight
- 130.08
- MOL File
- 106615-61-6.mol
5-Fluoropyrimidine-4,6-diol Property
- Density
- 1.73±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.42±0.10(Predicted)
Safety
- HazardClass
- IRRITANT
- HS Code
- 29335990
N-Bromosuccinimide Price
- Product number
- B435445
- Product name
- 5-Fluoropyrimidine-4,6-diol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- X8810
- Product name
- 5-Fluoropyrimidine-4,6-diol
- Packaging
- 1g
- Price
- $111
- Updated
- 2021/12/16
- Product number
- 059839
- Product name
- 5-Fluoropyrimidine-4,6-diol
- Purity
- >96%
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- CS-W000796
- Product name
- 5-fluoropyrimidine-4,6-diol
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 059839
- Product name
- 5-Fluoropyrimidine-4,6-diol
- Purity
- >96%
- Packaging
- 500mg
- Price
- $163
- Updated
- 2021/12/16
5-Fluoropyrimidine-4,6-diol Chemical Properties,Usage,Production
Uses
5-Fluoropyrimidine-4,6-diol is used in preparation of Phenylpyrimidine derivatives and analogs for use as Kynurenine-3-monooxygenase inhibitors.
Preparation
synthesis of 5-Fluoro-4,6-dihydroxypyrimidine: Formamidine acetate (2.06 g, 20 mmol) was added to the solution of sodium (1.38 g, 60 mmol) in anhydrous ethanol (40 mL) and the mixture was heated to reflux. Diethyl 2-fluoromalonate (3.20 g, 18 mmol) was added dropwise over 20 minutes and the mixture was heated at reflux for 6 h. After cooling to room temperature, the solution was evaporated to dryness, the residue was dissolved in water (20 mL), acidified with HCl (5 mL), the precipitate was filtered, washed with water (5 mL), ethanol (2 × 5 mL) and diethyl ether (2 × 5 mL). After drying in vacuo, 5-fluoro-4,6-dihydroxypyrimidine (1.50 g, 64%) was obtained as a brown powder.
m.p.: >300 °C; ([M + H]+ , 131.0244, C4H4FN2O2 requires: [M]+ , 131.0257); IR (neat, cm-1 ) 3053, 2639, 1633, 1547, 1388, 1213; δH (DMSO d6, 400 MHz) 7.90 (1H, s, C-H), 12.38 (2H, bs, OH); δF (DMSO d6, 376 MHz): -178.06 (s); δC (DMSO d6, 100 MHz) 132.79 (d, 1 JCF 235.6, C-F), 144.46 (d, 4 JCF 7.7, C-H), 155.83 (d, 2 JCF 15.0, C-OH); m/z (ASAP) 131 (100%, [M + H]+ ).21a
5-Fluoropyrimidine-4,6-diol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoropyrimidine-4,6-diol manufacturers
- Product
- 5-FLUORO-PYRIMIDINE-4,6-DIOL 106615-61-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-09
- Product
- 5-FLUORO-PYRIMIDINE-4,6-DIOL 106615-61-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-24