Amino-PEG4-Val-Cit-PAB-MMAE

Uses In Vitro Storage

Product Name: Amino-PEG4-Val-Cit-PAB-MMAE
CAS No.: 1492056-71-9
Chemical Name: Amino-PEG4-Val-Cit-PAB-MMAE
Synonyms: Amino-PEG4-Val-Cit-PAB-MMAE;Amino-PEG4-Val-Cit-PAB-MMAE USP/EP/BP;L-Valinamide, N-[[[4-[[N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-...;L-Valinamide, N-[[[4-[[N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
CBNumber: CB28054658
Molecular Formula: C69H115N11O17
Formula Weight: 1370.72
MOL File: 1492056-71-9.mol

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Amino-PEG4-Val-Cit-PAB-MMAE Property

Boiling point:: 1339.0±65.0 °C(Predicted)
Density: 1.171±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 13.29±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24414
Product name: Amino-PEG4-Val-Cit-PAB-MMAE
Purity: 98%
Packaging: 5mg
Price: $890
Updated: 2021/12/16

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Amino-PEG4-Val-Cit-PAB-MMAE Chemical Properties,Usage,Production

Uses

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Description

Amino-PEG4-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains an amino-PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.

Uses

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Amino-PEG4-Val-Cit-PAB-MMAE Preparation Products And Raw materials

Raw materials

Preparation Products

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Amino-PEG4-Val-Cit-PAB-MMAE Suppliers

China 27 United States 3 Global 30

Shanghai Send Pharmaceutical Technology Co., Ltd.

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View Lastest Price from Amino-PEG4-Val-Cit-PAB-MMAE manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Amino-PEG4-Val-Cit-PAB-MMAE 1492056-71-9
Price: US $0.00/mg
Min. Order: 10mg
Purity: >98.00%
Supply Ability: 10mg
Release date: 2024-03-29

1492056-71-9, Amino-PEG4-Val-Cit-PAB-MMAERelated Search:

Amino-PEG4-Val-Cit-PAB-MMAE

Amino-PEG4-Val-Cit-PAB-MMAE USP/EP/BP

L-Valinamide, N-[[[4-[[N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-...

L-Valinamide, N-[[[4-[[N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

1492056-71-9

ADC LINKER