2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
- Product Name
- 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
- CAS No.
- 2188236-41-9
- Chemical Name
- 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
- Synonyms
- APS6-45;APS6-45 ，S3493;APS6-45, 10 mM in DMSO;4-(4-(3-(2-Fluoro-5-(perfluoropropan-2-yl)phenyl)ureido)phenoxy)-N-methylpicolinamide;4-[4-[[2-fluoro-5-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;APS6-45,calibrated,signaling,TCI,Inhibitor,APS-6-45,APS645,Carcinoma,Thyroid,Ras,antitumor,Medullary,MAPK,APS6 45,tumor,inhibit;2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
- CBNumber
- CB28093648
- Molecular Formula
- C23H16F8N4O3
- Formula Weight
- 548.39
- MOL File
- 2188236-41-9.mol
2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- Property
- solubility
- DMF: 5 mg/ml
DMSO: 10 mg/ml
Ethanol: 10 mg/ml - form
- Solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P331Do NOT induce vomiting.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 38417
- Product name
- APS6-45
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $29
- Updated
- 2026/04/30
- Product number
- 38417
- Product name
- APS6-45
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $113
- Updated
- 2026/04/30
- Product number
- 38417
- Product name
- APS6-45
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $197
- Updated
- 2026/04/30
- Product number
- 38417
- Product name
- APS6-45
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $247
- Updated
- 2026/04/30
- Product number
- CS-0089605
- Product name
- APS6-45
- Purity
- 99.92%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- Chemical Properties,Usage,Production
Uses
APS6-45 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity[1].
in vivo
APS6-45 (10 mg/kg; p.o. daily for 30 d) inhibits growth of TT tumors in mice and does not affect body weight[1].
APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice[1].
APS6-45 (20 mg/kg; a single p.o.) exhibits long half-life (5.6 h), Cmax (9.7 μM) and AUC0-24 (123.7 μMh) in mice[1].
| Animal Model: | Female nude mice (6 weeks) are implanted with TT cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | P.o. daily for 30 days |
| Result: | Led to partial or complete responses in 75% and was well tolerated. |
| Animal Model: | Male ICR mice (6 weeks of age)[1] |
| Dosage: | 20 mg/kg (Pharmacokinetic Analysis) |
| Administration: | A single p.o. |
| Result: | T1/2=5.6 h, Cmax=9.7 μM, AUC0-24=123.7 μMh. |
References
[1] Sonoshita M, et, al. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol. 2018 Mar;14(3):291-298. DOI:10.1038/nchembio.2556
2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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