ChemicalBook > CAS DataBase List > 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-

2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-

Product Name
2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
CAS No.
2188236-41-9
Chemical Name
2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
Synonyms
APS6-45;APS6-45 ，S3493;APS6-45, 10 mM in DMSO;4-(4-(3-(2-Fluoro-5-(perfluoropropan-2-yl)phenyl)ureido)phenoxy)-N-methylpicolinamide;4-[4-[[2-fluoro-5-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;APS6-45,calibrated,signaling,TCI,Inhibitor,APS-6-45,APS645,Carcinoma,Thyroid,Ras,antitumor,Medullary,MAPK,APS6 45,tumor,inhibit;2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
CBNumber
CB28093648
Molecular Formula
C23H16F8N4O3
Formula Weight
548.39
MOL File
2188236-41-9.mol
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2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- Property

solubility 
DMF: 5 mg/ml
DMSO: 10 mg/ml
Ethanol: 10 mg/ml
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0089605
Product name
APS6-45
Purity
99.92%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0089605
Product name
APS6-45
Purity
99.92%
Packaging
10mg
Price
$580
Updated
2021/12/16
ChemScene
Product number
CS-0089605
Product name
APS6-45
Purity
99.92%
Packaging
25mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0089605
Product name
APS6-45
Purity
99.92%
Packaging
50mg
Price
$1700
Updated
2021/12/16
ChemScene
Product number
CS-0089605
Product name
APS6-45
Purity
99.92%
Packaging
100mg
Price
$2500
Updated
2021/12/16
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2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- Chemical Properties,Usage,Production

Uses

APS6-45 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity[1].

in vivo

APS6-45 (10 mg/kg; p.o. daily for 30 d) inhibits growth of TT tumors in mice and does not affect body weight[1].
APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice[1].
APS6-45 (20 mg/kg; a single p.o.) exhibits long half-life (5.6 h), Cmax (9.7 μM) and AUC0-24 (123.7 μMh) in mice[1].

Animal Model:Female nude mice (6 weeks) are implanted with TT cells[1]
Dosage:10 mg/kg
Administration:P.o. daily for 30 days
Result:Led to partial or complete responses in 75% and was well tolerated.
Animal Model:Male ICR mice (6 weeks of age)[1]
Dosage:20 mg/kg (Pharmacokinetic Analysis)
Administration:A single p.o.
Result:T1/2=5.6 h, Cmax=9.7 μM, AUC0-24=123.7 μMh.

References

[1] Sonoshita M, et, al. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol. 2018 Mar;14(3):291-298. DOI:10.1038/nchembio.2556

2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- Suppliers

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2188236-41-9, 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-Related Search:


  • 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
  • APS6-45
  • APS6-45,calibrated,signaling,TCI,Inhibitor,APS-6-45,APS645,Carcinoma,Thyroid,Ras,antitumor,Medullary,MAPK,APS6 45,tumor,inhibit
  • 4-(4-(3-(2-Fluoro-5-(perfluoropropan-2-yl)phenyl)ureido)phenoxy)-N-methylpicolinamide
  • APS6-45, 10 mM in DMSO
  • 4-[4-[[2-fluoro-5-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
  • APS6-45 ，S3493
  • 2188236-41-9
  • C23H16F8N4O3