ChemicalBook > CAS DataBase List > 7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-

Product Name
7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-
CAS No.
2254693-15-5
Chemical Name
7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-
Synonyms
SRX3207;SRX-3207,SRX3207;7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-
CBNumber
CB28095086
Molecular Formula
C29H29N7O3S
Formula Weight
555.65
MOL File
2254693-15-5.mol
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7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Property

storage temp. 
Store at -20°C
solubility 
DMSO : 5 mg/mL (9.00 mM; Need ultrasonic)
form 
Solid
color 
Light yellow to light brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0120685
Product name
SRX3207
Purity
98.92%
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0120685
Product name
SRX3207
Purity
98.92%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0120685
Product name
SRX3207
Purity
98.92%
Packaging
25mg
Price
$1350
Updated
2021/12/16
ChemScene
Product number
CS-0120685
Product name
SRX3207
Purity
98.92%
Packaging
50mg
Price
$2200
Updated
2021/12/16
ChemScene
Product number
CS-0120685
Product name
SRX3207
Purity
98.92%
Packaging
100mg
Price
$3400
Updated
2021/12/16
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7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Chemical Properties,Usage,Production

Uses

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2].

Biological Activity

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2]. SRX3207 (10 μmol/L) is able to block p-AKT at concentration[1].SRX3207 has sufficient solubility in water (43 μmol/L)[1]. SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

in vivo

SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

Animal Model:LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice[1].
Dosage:10 mg/kg.
Administration:Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result:Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.

IC 50

Syk: 10.7 nM (IC50); PI3Kα: 861 nM (IC50); PI3Kδ: 1280 nM (IC50); PI3Kγ: 11100 nM (IC50); Zap70: 1300 nM (IC50)

References

[1]. Shweta Joshi, et al. Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Molecular Cancer Therapeutics. 2020. [2]. Shweta Joshi, et al. Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Mol Cancer Ther. 2020 Mar;19(3):755-764.

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Suppliers

CHINA 30 United States 3 Global 33
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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021-QQ：65489617 15618227136
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Sales@ATKchemical.com
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InvivoChem
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Nantong Hi-Future Biotechnology Co., Ltd
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18051384581
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sales@chemhifuture.com
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InvivoChem
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13549236410
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Changzhou Borl Biotechnology Co.,LTD
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2254693-15-5, 7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-Related Search:


  • 7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-
  • SRX3207
  • SRX-3207,SRX3207
  • 2254693-15-5
  • C29H29N7O3S