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AZ32

Product Name
AZ32
CAS No.
2288709-96-4
Chemical Name
AZ32
Synonyms
AZ32;AZ32, 10 mM in DMSO;N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide;Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-;Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
CBNumber
CB28095233
Molecular Formula
C20H16N4O
Formula Weight
328.37
MOL File
2288709-96-4.mol
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AZ32 Property

Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 150 mg/ml
form 
A solid
pka
14.63±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2551
Product name
AZ32
Purity
≥98% (HPLC)
Packaging
5MG
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2551
Product name
AZ32
Purity
≥98% (HPLC)
Packaging
25MG
Price
$494
Updated
2024/03/01
Cayman Chemical
Product number
26380
Product name
AZ 32
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
26380
Product name
AZ 32
Purity
≥98%
Packaging
5mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
26380
Product name
AZ 32
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
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AZ32 Chemical Properties,Usage,Production

Biological Activity

AZ32 is an oral, blood-brain barrier-penetrating ATM inhibitor with IC50<6.2 nM. Inhibits ATM in cells with IC50 of 0.31 μM.

in vitro

AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.

in vivo

AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours.

AZ32 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ32 Suppliers

China 34 India 1 United States 6 Global 41
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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ShangHai Biochempartner Co.,Ltd
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Shanghai Rechem science Co., Ltd.
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21-31433387 15618786686
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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010-50973130 4009686088
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Beijing Jin Ming Biotechnology Co., Ltd.
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DC Chemicals
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Energy Chemical
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InvivoChem
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TargetMol Chemicals Inc.
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2288709-96-4, AZ32Related Search:


  • Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-
  • N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
  • AZ32
  • Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
  • AZ32, 10 mM in DMSO
  • 2288709-96-4