ChemicalBook > CAS DataBase List > AZ32

AZ32

Product Name: AZ32
CAS No.: 2288709-96-4
Chemical Name: AZ32
Synonyms: AZ32;AZ32 ，S8729;AZ32, 10 mM in DMSO;N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide;Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-;Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
CBNumber: CB28095233
Molecular Formula: C20H16N4O
Formula Weight: 328.37
MOL File: 2288709-96-4.mol

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AZ32 Property

Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 150 mg/ml
form: A solid
pka: 14.63±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2551
Product name: AZ32
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $93.55
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2551
Product name: AZ32
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $382
Updated: 2025/07/31

Cayman Chemical

Product number: 26380
Product name: AZ 32
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 26380
Product name: AZ 32
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 26380
Product name: AZ 32
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

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AZ32 Chemical Properties,Usage,Production

Uses

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.

Biological Activity

AZ32 is an oral, blood-brain barrier-penetrating ATM inhibitor with IC50<6.2 nM. Inhibits ATM in cells with IC50 of 0.31 μM.

in vitro

AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.

in vivo

AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC ₅₀ for approximately 22 hours.

IC 50

ATM: 6.2 nM (IC₅₀); ATM: 0.31 μM (IC₅₀, in cell)

References

[1] Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. DOI:10.1158/1535-7163.MCT-17-0975

AZ32 Preparation Products And Raw materials

Raw materials

Preparation Products

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2288709-96-4, AZ32Related Search:

Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-

N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide

AZ32

Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR

AZ32, 10 mM in DMSO

AZ32 ，S8729

2288709-96-4