ChemicalBook > CAS DataBase List > PF-06928215
PF-06928215
- Product Name
- PF-06928215
- CAS No.
- 2378173-15-8
- Chemical Name
- PF-06928215
- Synonyms
- PF-06928215;PF-06928215, 10 mM in DMSO;Inhibitor,PF-06928215,cGAS,inhibit,PF 06928215,Cyclic GMP-AMP Synthase,PF06928215;(1R,2S)-2-(7-Hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamido)cyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 2-[[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)carbonyl]amino]-, (1R,2S)-
- CBNumber
- CB28096285
- Molecular Formula
- C20H20N4O4
- Formula Weight
- 380.4
- MOL File
- 2378173-15-8.mol
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PF-06928215 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 30 mg/ml
- form
- A solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0078781
- Product name
- PF-06928215
- Purity
- >99.0%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN23557
- Product name
- PF-06928215
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
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PF-06928215 Chemical Properties,Usage,Production
Uses
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd)[1].
Biological Activity
PF-06928215 is a high-affinity cGAS (cyclic GMP-AMP Synthase) inhibitor with IC50 of 4.9 μM and affinity Kd value of 0.2 μM.
in vitro
PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression.
References
[1] Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843. DOI:10.1371/journal.pone.0184843
PF-06928215 Preparation Products And Raw materials
Raw materials
Preparation Products
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