DERAMCICLANE

Product Name: DERAMCICLANE
CAS No.: 120444-71-5
Chemical Name: DERAMCICLANE
Synonyms: EGIS-3886;DERAMCLCLANE;DERAMCICLANE;DERAMCICLANE ISO 9001：2015 REACH;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine;Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-
CBNumber: CB2818661
Molecular Formula: C20H31NO
Formula Weight: 301.47
MOL File: 120444-71-5.mol

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DERAMCICLANE Property

Boiling point:: 375.2±25.0 °C(Predicted)
Density: 1.01±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0007969
Product name: DERAMCICLANE
Purity: 95.00%
Packaging: 5MG
Price: $500.31
Updated: 2021/12/16

CSNpharm

Product number: CSN21600
Product name: Deramciclane
Packaging: 25mg
Price: $1225
Updated: 2021/12/16

CSNpharm

Product number: CSN21600
Product name: Deramciclane
Packaging: 1mg
Price: $204
Updated: 2021/12/16

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DERAMCICLANE Chemical Properties,Usage,Production

in vitro

Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT _2A / _2C receptors. The interactions of Deramciclane with the serotonin 5-HT _2C receptor are further characterized using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT _2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC ₅₀ value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC ₅₀ = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.

in vivo

Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT _2A and 5-HT _2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT _{2C < /sub> receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.}

DERAMCICLANE Preparation Products And Raw materials

Raw materials

Preparation Products

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DERAMCICLANE Suppliers

China 12 United States 7 Global 19

China Langchem Inc.

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shanghai cooperpharm co.,LTD .

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Shanghai ChuangYan Chemical Technology Co., Ltd.

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Amadis Chemical Company Limited

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Fan De(Beijing) Biotechnology Co., Ltd.

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Country: China
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TargetMol Chemicals Inc.

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Shaanxi Dideu Medichem Co. Ltd

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Kaifeng Mingren Pharmaceutical Co.,LTD

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120444-71-5, DERAMCICLANERelated Search:

Naphthenic oil (+/-)-ISOBORNYL METHYL ETHER DERAMCICLANE 1-PHENYL-1-CYCLOPENTANOL 2-METHYLISOBORNEOL DL-Isoborneol 2,2-DIMETHYL-1-PHENYL-1-PROPANOL CYCLOPENTYLPHENYLMETHANOL 1-PHENYLCYCLOHEXANOL

DERAMCICLANE

DERAMCLCLANE

N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine

N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine

N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine

EGIS-3886

Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-

N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine

DERAMCICLANE ISO 9001：2015 REACH

120444-71-5