DERAMCICLANE

Product Name: DERAMCICLANE
CAS No.: 120444-71-5
Chemical Name: DERAMCICLANE
Synonyms: EGIS-3886;DERAMCLCLANE;DERAMCICLANE;DERAMCICLANE ISO 9001：2015 REACH;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine;Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethan-1-amine
CBNumber: CB2818661
Molecular Formula: C20H31NO
Formula Weight: 301.47
MOL File: 120444-71-5.mol

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DERAMCICLANE Property

Boiling point:: 375.2±25.0 °C(Predicted)
Density: 1.01±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)
form: Oil
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0007969
Product name: DERAMCICLANE
Purity: 95.00%
Packaging: 5MG
Price: $500.31
Updated: 2021/12/16

CSNpharm

Product number: CSN21600
Product name: Deramciclane
Packaging: 25mg
Price: $1225
Updated: 2021/12/16

CSNpharm

Product number: CSN21600
Product name: Deramciclane
Packaging: 1mg
Price: $204
Updated: 2021/12/16

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DERAMCICLANE Chemical Properties,Usage,Production

Uses

Deramciclane has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist.

in vitro

Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT _2A / _2C receptors. The interactions of Deramciclane with the serotonin 5-HT _2C receptor are further characterized using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT _2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC ₅₀ value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC ₅₀ = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.

in vivo

Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT _2A and 5-HT _2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT _{2C < /sub> receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.}

IC 50

5-HT_2A Receptor; 5-HT_2C Receptor

References

[1] P?lvim?ki EP, et al. Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation. Psychopharmacology (Berl). 1998 Mar;136(2):99-104. DOI:10.1007/s002130050544
[2] K??ri?inen TM, et al. Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats. Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):50-8. DOI:10.1111/j.1742-7843.2007.00145.x

DERAMCICLANE Preparation Products And Raw materials

Raw materials

Preparation Products

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DERAMCICLANE Suppliers

China 19 United States 9 Global 28

China Langchem Inc.

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Amadis Chemical Company Limited

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Shaanxi Dideu Medichem Co. Ltd

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120444-71-5, DERAMCICLANERelated Search:

Naphthenic oil (+/-)-ISOBORNYL METHYL ETHER DERAMCICLANE 1-PHENYL-1-CYCLOPENTANOL 2-METHYLISOBORNEOL DL-Isoborneol 2,2-DIMETHYL-1-PHENYL-1-PROPANOL CYCLOPENTYLPHENYLMETHANOL 1-PHENYLCYCLOHEXANOL

DERAMCICLANE

DERAMCLCLANE

N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine

N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine

N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine

EGIS-3886

Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-

N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine

DERAMCICLANE ISO 9001：2015 REACH

N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethan-1-amine

120444-71-5