(S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE

Product Name: (S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE
CAS No.: 2189684-54-4
Chemical Name: (S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE
Synonyms: Lenacapavir Intermediate 2;intermediate of Lenacapavir;Lenacapavir (GS-6207) Intermediate 2;tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate;(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate;Tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2- 260 yl)-2-(3,5-difluorophenyl)ethyl)carbamate;(S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate tert-butyl ester;tert-butyl(S)-(1-(3-bromine-6-(3-methyl-3-(Methylsulfonyl)- 1-Alkyne-1-base)Pyridine-2-base)-2-(3,5-Difluorophenyl)Ethyl)Carbamate;N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-, 1,1-dimethylethyl ester;1,1-Dimethylethyl N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]carbamate
CBNumber: CB28189080
Molecular Formula: C24H27BrF2N2O4S
Formula Weight: 557.45
MOL File: 2189684-54-4.mol

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(S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE Property

Boiling point:: 636.8±55.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
pka: 10.37±0.46(Predicted)
InChIKey: OBUPKGOLRNAZIS-FQEVSTJZSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@H](C1=NC(C#CC(C)(S(C)(=O)=O)C)=CC=C1Br)CC1=CC(F)=CC(F)=C1

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Hazard and Precautionary Statements (GHS)

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(S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE Chemical Properties,Usage,Production

Uses

(S)-Tert-butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-YN-1-YL)pyridin-2-YL)-2-(3,5-difluorophenyl)ethyl)carbamate is a pharmaceutical intermediate compound that can be used in the preparation of HIV inhibitors.

Description

(S)-tert-butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate is a key pharmaceutical intermediate for lenapavir (trade name Sunlenca), used in the synthesis of anti-HIV-1 drugs. Lenapavir is a first-in-class long-acting HIV-1 capsid inhibitor administered subcutaneously, providing a prolonged treatment period, significantly reducing the treatment burden on patients, and exhibiting potent antiviral activity against drug-resistant HIV strains.

(S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE Suppliers

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View Lastest Price from (S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATE manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: Lenacapavir (GS-6207) Intermediate 2 2189684-54-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2025-07-08

Hangzhou ICH Biofarm Co., Ltd

Product: Lenacapavir (GS-6207) Intermediate 2 2189684-54-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2025-02-06

Hangzhou ICH Biofarm Co., Ltd

Product: Lenacapavir (GS-6207) Intermediate 2 2189684-54-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2025-02-06

2189684-54-4, (S)-TERT-BUTYL (1-(3-BROMO-6-(3-METHYL-3-(METHYLSULFONYL)BUT-1-YN-1-YL)PYRIDIN-2-YL)-2-(3,5-DIFLUOROPHENYL)ETHYL)CARBAMATERelated Search:

Carbamic acid, N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-, 1,1-dimethylethyl ester

Carbanic acid,N-[CIS)-1-[3-bromo-6-[3-methyl-3(methyl)sulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-,1,1-dimethylethylester

tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

intermediate of Lenacapavir

(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2- 260 yl)-2-(3,5-difluorophenyl)ethyl)carbamate

1,1-Dimethylethyl N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]carbamate

Lenacapavir (GS-6207) Intermediate 2

Lenacapavir Intermediate 2

tert-butyl(S)-(1-(3-bromine-6-(3-methyl-3-(Methylsulfonyl)- 1-Alkyne-1-base)Pyridine-2-base)-2-(3,5-Difluorophenyl)Ethyl)Carbamate

N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-, 1,1-dimethylethyl ester

(S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate tert-butyl ester

2189684-54-4

C24H27BrF2N2O4S