EST64454

Product Name: EST64454
CAS No.: 1950569-11-5
Chemical Name: EST64454
Synonyms: EST64454;EST64454 HCl;EST64454 hydrochloride;EST64454 hydrochloride, 10 mM in DMSO;pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit
CBNumber: CB28210252
Molecular Formula: C18H23ClF2N4O2
Formula Weight: 400.85
MOL File: 1950569-11-5.mol

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EST64454 Property

storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (249.47 mM; Need ultrasonic)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0144561
Product name: EST64454hydrochloride
Purity: 99.19%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0144561
Product name: EST64454hydrochloride
Purity: 99.19%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0144561
Product name: EST64454hydrochloride
Purity: 99.19%
Packaging: 25mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0144561
Product name: EST64454hydrochloride
Purity: 99.19%
Packaging: 50mg
Price: $1450
Updated: 2021/12/16

ChemScene

Product number: CS-0144561
Product name: EST64454hydrochloride
Purity: 99.19%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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EST64454 Chemical Properties,Usage,Production

Biological Activity

EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain[1]. EST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively[1].EST64454 (10 mg/kg; p.o.; male CD1 mice) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% were 1178 ng/mL, <1 hours, 2645 ng h/mL, 1.2 l/kg and 60%, respectively[1].

References

[1]. Díaz JL, et al. EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem. 2020;63(23):14979-14988.

EST64454 Preparation Products And Raw materials

Raw materials

Preparation Products

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EST64454 Suppliers

China 14 United States 3 Global 17

Shanghai Chaolan Chemical Technology Center

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DC Chemicals

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Wuhan Augda Biotechnology Co., Ltd

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InvivoChem

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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Tel
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1950569-11-5, EST64454Related Search:

EST64454

EST64454 hydrochloride

EST64454 HCl

pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit

EST64454 hydrochloride, 10 mM in DMSO

1950569-11-5