ChemicalBook > CAS DataBase List > EST64454
EST64454
- Product Name
- EST64454
- CAS No.
- 1950569-11-5
- Chemical Name
- EST64454
- Synonyms
- EST64454;EST64454 HCl;EST64454 hydrochloride;EST64454 hydrochloride, 10 mM in DMSO;pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit
- CBNumber
- CB28210252
- Molecular Formula
- C18H23ClF2N4O2
- Formula Weight
- 400.85
- MOL File
- 1950569-11-5.mol
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EST64454 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (249.47 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0144561
- Product name
- EST64454hydrochloride
- Purity
- 99.19%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0144561
- Product name
- EST64454hydrochloride
- Purity
- 99.19%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0144561
- Product name
- EST64454hydrochloride
- Purity
- 99.19%
- Packaging
- 25mg
- Price
- $950
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0144561
- Product name
- EST64454hydrochloride
- Purity
- 99.19%
- Packaging
- 50mg
- Price
- $1450
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0144561
- Product name
- EST64454hydrochloride
- Purity
- 99.19%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
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EST64454 Chemical Properties,Usage,Production
Biological Activity
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain[1]. EST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively[1].EST64454 (10 mg/kg; p.o.; male CD1 mice) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% were 1178 ng/mL, <1 hours, 2645 ng h/mL, 1.2 l/kg and 60%, respectively[1].
References
[1]. Díaz JL, et al. EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem. 2020;63(23):14979-14988.
EST64454 Preparation Products And Raw materials
Raw materials
Preparation Products
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EST64454 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
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- Advantage
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- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
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- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38631
- Advantage
- 58