ChemicalBook > CAS DataBase List > Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate

Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate

Product Name: Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate
CAS No.: 1221412-23-2
Chemical Name: Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate
Synonyms: IMM-H007;WS070117;IMM-H007, 10 mM in DMSO;triacetyl-3-hydroxyphenyladenosine;Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate;(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-((3-hydroxyphenyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate;JNK,Nuclear factor-κB,WS 070117,IMM H007,AP-1,inflammatory,WS070117,inhibit,AMPK,atherosclerosis,IMM-H007,Transforming growth factor beta receptors,Activator Protein 1,cardiac fibrosis,IMM-H-007,JNK/c-Jun,IMMH007,NF-κB,Nonalcoholic fatty liver disease,NAFLD,WS-070117,TGF-β Receptor,AMP-activated protein kinase,Nuclear factor-kappaB,Inhibitor
CBNumber: CB28236043
Molecular Formula: C22H23N5O8
Formula Weight: 485.45
MOL File: 1221412-23-2.mol

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Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate Property

Boiling point:: 684.6±65.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 97 mg/mL (199.81 mM);Ethanol: Insoluble
pka: 9.56±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC42561
Product name: IMM-H007
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate Chemical Properties,Usage,Production

Uses

IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis[1][2][3].

in vivo

IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids^[2].
IMM-H007 (200?mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent^[3].

References

[1] Yu J, et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling. Toxicol Appl Pharmacol. 2019 Oct 15;381:114732. DOI:10.1016/j.taap.2019.114732
[2] Shi H, et al. IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet. FEBS Open Bio. 2017 Aug 29;7(9):1379-1391. DOI:10.1002/2211-5463.12272
[3] Wang SX, et al. IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway. Acta Pharmacol Sin. 2022 Mar 30. DOI:10.1038/s41401-022-00899-2

Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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1221412-23-2, Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetateRelated Search:

Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate

IMM-H007

JNK,Nuclear factor-κB,WS 070117,IMM H007,AP-1,inflammatory,WS070117,inhibit,AMPK,atherosclerosis,IMM-H007,Transforming growth factor beta receptors,Activator Protein 1,cardiac fibrosis,IMM-H-007,JNK/c-Jun,IMMH007,NF-κB,Nonalcoholic fatty liver disease,NAFLD,WS-070117,TGF-β Receptor,AMP-activated protein kinase,Nuclear factor-kappaB,Inhibitor

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-((3-hydroxyphenyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

triacetyl-3-hydroxyphenyladenosine

IMM-H007, 10 mM in DMSO

WS070117

1221412-23-2