ChemicalBook > CAS DataBase List > 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID

2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID

Product Name
2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID
CAS No.
1374208-42-0
Chemical Name
2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID
Synonyms
EOS-62377;-AMINO-4-BROMO-5-FLUOROBENZOIC ACID;2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID;Benzoic acid, 2-amino-4-bromo-5-fluoro-;2-amino-4-bromo-5-fluorobenzoicacidhydrochloride
CBNumber
CB2835419
Molecular Formula
C7H5BrFNO2
Formula Weight
234.02
MOL File
Mol file
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2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID Property

Boiling point:
353.6±42.0 °C(Predicted)
Density 
1.877±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
4.37±0.10(Predicted)
form 
lumpy powder
color 
Pale yellow/gold
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Safety

HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A595145
Product name
2-amino-4-bromo-5-fluorobenzoicacid
Packaging
100mg
Price
$265
Updated
2021/12/16
SynQuest Laboratories
Product number
4657-B-03
Product name
2-Amino-4-bromo-5-fluorobenzoic acid
Packaging
1g
Price
$282
Updated
2021/12/16
AK Scientific
Product number
5013DT
Product name
2-Amino-4-bromo-5-fluorobenzoicacid
Packaging
250mg
Price
$119
Updated
2021/12/16
SynQuest Laboratories
Product number
4657-B-03
Product name
2-Amino-4-bromo-5-fluorobenzoic acid
Packaging
250mg
Price
$149
Updated
2021/12/16
Acrotein
Product number
UT01234
Product name
2-Amino-4-bromo-5-fluorobenzoicacid
Purity
97%
Packaging
1g
Price
$231.17
Updated
2021/12/16
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2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID Chemical Properties,Usage,Production

Synthesis

1020717-99-0

1374208-42-0

General procedure for the synthesis of 2-amino-4-bromo-5-fluorobenzoic acid from 4-bromo-5-fluoro-2-nitrobenzoic acid: 5% Pt/C (50% aqueous wet, 60 g, 6 wt%) was added to a nitrogen-protected reaction vessel containing isopropyl acetate (22 L) and 4-bromo-5-fluoro-2-nitrobenzoic acid (1.00 kg, 3.79 mol). The headspace of the reaction vessel was displaced three times with nitrogen and then three times with hydrogen. The reaction mixture was stirred at 25 °C and under hydrogen atmosphere. after 40 h, the reaction was completed and the headspace was again replaced three times with nitrogen. The reaction mixture was filtered and the reaction vessel and filter were rinsed with isopropyl acetate (5 L). The organic layers were combined and concentrated under reduced pressure to 5.0 L. Subsequently, the solvent was replaced with toluene under reduced pressure, and the solid obtained was separated by filtration, washed with toluene, and dried under reduced pressure at 50 °C to give 0.59 kg (66% yield) of 2-amino-4-bromo-5-fluorobenzoic acid as a white to off-white crystalline solid.

References

[1] Organic Letters, 2018, vol. 20, # 13, p. 3736 - 3740
[2] Patent: WO2018/118830, 2018, A1. Location in patent: Page/Page column 25-26
[3] Patent: WO2017/192304, 2017, A1. Location in patent: Paragraph 0378

2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID Suppliers

China 67 India 1 United Kingdom 1 United States 5 Global 74
PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
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86-025-86918232
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sales@pharmablock.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
Email
sales8178@energy-chemical.com
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China
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Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
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2355560935@qq.com
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China
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Beijing Eternalchem Co,. Ltd.
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010-59484199 18611897322
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sales@eternalchem.com
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China
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Tianjin Jinyuda Chemical Co., Ltd.
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022-58013646 13011382049
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022-23854368
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sales@jinyudachem.com
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China
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SuZhou ShiYa Biopharmaceuticals, Inc.
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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ShangHai AmK Pharmaceutical Technology Co., Ltd.
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微信 17321281695 18019252918
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17321281695
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sale@amkchem.com
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China
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Quzhou AMK BioTech Co., Ltd
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0570-3081766 18357083060
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0570-3072337
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sales@qzamkbio.com
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China
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Shanghai Haozhixiang Biotechnology Co., Ltd
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526763801 13301653310
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+86-21-51619052
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526763801@qq.com
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View Lastest Price from 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID manufacturers

Career Henan Chemical Co
Product
2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID 374208-42-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13
Career Henan Chemical Co
Product
2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID 1374208-42-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13
Career Henan Chemical Co
Product
2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID 1374208-42-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13

1374208-42-0, 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACIDRelated Search:

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