ChemicalBook > CAS DataBase List > cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

Product Name
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
CAS No.
134071-44-6
Chemical Name
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
Synonyms
CIS-TOSYLATE;Active Ester;Activity Ester;K6 / Cis Tosylate;oxymethyl-1,3-dioxolane;Ketoconazole IMpurity E;KETOCOZOLE EP IMPURITY E;Ketoconazole EP Impurity E;ACTIVE ESTER OF KETOCONZOL;Activity Esterof Ketoconazo
CBNumber
CB2855192
Molecular Formula
C21H20Cl2N2O5S
Formula Weight
483.36
MOL File
134071-44-6.mol
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cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Property

Melting point:
120-122°C
Boiling point:
665.7±55.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.88±0.12(Predicted)
color 
White to Off-White
InChI
InChI=1/C21H20Cl2N2O5S/c1-15-2-5-18(6-3-15)31(26,27)29-12-17-11-28-21(30-17,13-25-9-8-24-14-25)19-7-4-16(22)10-20(19)23/h2-10,14,17H,11-13H2,1H3/t17-,21-/s3
InChIKey
WAXNIYHZFWRPGS-NTMXNBFVNA-N
SMILES
[C@@]1(OC[C@@H](COS(=O)(=O)C2C=CC(C)=CC=2)O1)(CN1C=NC=C1)C1=CC=C(Cl)C=C1Cl |&1:0,3,r|
CAS DataBase Reference
134071-44-6(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P402+P404Store in a dry place. Store in a closed container.

P422Store contents under …

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
099380
Product name
(cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate
Packaging
250.00mg
Price
$341
Updated
2026/05/18
Matrix Scientific
Product number
099380
Product name
(cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate
Packaging
1.00g
Price
$756
Updated
2026/05/18
Arctom
Product number
BD-A112944
Product name
trans-Ketoconazole EP Impurity E
Purity
95%
Packaging
1g
Price
$9
Updated
2026/05/25
Arctom
Product number
BD-A112944
Product name
trans-Ketoconazole EP Impurity E
Purity
95%
Packaging
5g
Price
$10
Updated
2026/05/25
Arctom
Product number
BD-A112944
Product name
trans-Ketoconazole EP Impurity E
Purity
95%
Packaging
10g
Price
$16
Updated
2026/05/25
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cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-Tolylsulfonate (Ketoconazole EP Impurity E) is an intermediate in the synthesis of the drug Ketoconazole (K186000).

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

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cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Suppliers

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Conier Chem & Pharma Co.,Ltd,
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+86-15716293042;0513-68015397;15716293042 18862997610;18862996710
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View Lastest Price from cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate manufacturers

Qiuxian Baitai New Material Co., LTD
Product
Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester 134071-44-6
Price
US $2.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-12-21
Career Henan Chemical Co
Product
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate 134071-44-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-24

134071-44-6, cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonateRelated Search:

Mebendazole Imidazole Dichlorodiphenylsilane Dichloromethylphenylsilane Phenylphosphonic dichloride Ketoconazole Ketoconazole Impurity 1 Ketoconazole Impurity 4 Ketoconazole Impurity 9 (Ketoconazole Hydroxymethyl Impurity) Ketoconazole Impurity 6 Ketoconazole Impurity 15 KETOCONAZOLE INTERMEDIATE cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine 2,3-Dehydro Ketoconazole N-Acetylpiperazine-N'-(4-phenol) Ketoconazole rac-trans-Ketoconazole Ketoconazole Impurity 2 KetoconazoleN-Oxide

  • cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
  • CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENE SULFONYLOXY) METHYL-1,3-DIOXALANE
  • CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-YL METHYL)-1,3-DIOXOLANE-4-YL]-P-METHYLBENZENE SULFONATE
  • CIS-TOSYLATE
  • ACTIVITY ESTEROF KETOCONAZOL
  • CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-YL METHYL)-1,3-DIOXOLANE-4-YL]-P-METHYLBENZENE SULFONATE OR -P-METHYL SULFONATE (KETOCONAZLE INTERMEDIATE)
  • Ketoconazole EP Impurity E
  • Cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-l-ylmethyl)- 1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (CisTosylate)
  • Ketoconazole Impurity 5（Ketoconazole EP Impurity E）
  • 2-[[2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methyl]-4-methylbenzenesulfonate
  • CIS-2-(2 4- DICHLOROPHENYL)-2-(1-H-IMIDA ZOLE-YL-METHYL) -1 3-DIOXOLAN-4-YL] METH YL-4-METHYLBENZENESULPHONATE
  • CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENESULFONYLOXY)METHYL-1,3-DIOXALANE
  • Cis-Tosylate(Cis-2-Dichlorophenyl)2-(Ih-Imidazole-1-Yl)Methyl-4-(P-TolueneSulfonyloxy)Methyl-1,3-Dioxalane
  • CIS-[2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL-4-TOLYLSULFONATE
  • Active Ester
  • 1,3-Dioxolane-4-Methanol,2-(2,4-dichlorophenyl)-2-(1H-iMidazol-1-ylMethyl)-,4-(4-Methylbenzenesulfonate), (2R,4R)-rel-
  • (2R,4R)-rel-2-(2,4-Dichlorophenyl)-2-(1H-iMidazol-1-ylMethyl)-1,3-dioxolane-4-Methanol 4-(4-Methylbenzenesulfonate)
  • CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENE SUIFONYLOXY)METHYL-1,3-
  • Cis-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1yl-methyl)-4-(p-toluensulfonyl)
  • oxymethyl-1,3-dioxolane
  • (Z)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmeth
  • (cis-2-((1H-IMidazol-1-yl)Methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)Methyl 4-Methylbenzenesulfonate
  • Ketoconazole IMpurity E
  • Activity Esterof Ketoconazo
  • Activity Ester
  • ((2R,4R)-rel-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate
  • (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenz
  • CIS-TOSYLATE, CIS-[2-2,4-DICHLOROPHENYL]-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL-4-METHYLBENZENESULPHONATE
  • (2R,4R) CIS-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE
  • CIS-[2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXALAN-4-YL]METHYL-P-TOLYSULFONATE
  • (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzene
  • Cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (134071-44-6)
  • [(2RS,4SR)-2-(2,4-Dichlorophenyl)-2
  • CIS TOSYLATE : Cis-2-(2,4-Dichlorophenyl)-2-(1H-Imidazole-1-yl)Methyl)-4-(p-Toluene Sulfonyloxy)methyl-1,3-Dioxalane)
  • ACTIVE ESTER OF KETOCONZOL
  • Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester
  • cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-d...
  • K6 / Cis Tosylate
  • [(2RS,4SR)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate
  • KETOCOZOLE EP IMPURITY E
  • Cis-(2-(2,4-Dichlorophenyl)-2-(lH- Imidazot-1- yl-Methyl)-1,3- Dioxolan-4-yl}methyl-4-Methanol
  • CIS-[2-2,4-DICHLOROPHENYL-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4YL]METHYL-4-METHYLBENZENESULPHONATE(Cis Tosylate)
  • Ketoconazole Intermediate 1e
  • (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesul
  • [(2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate
  • (2RS,4SR)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-Methylbenzen
  • cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
  • Ketoconazole Imp.E(EP): [(2RS,4SR)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methyl 4-methylbenzene-1-sulfonate
  • CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOL METHYL-4-METHYI
  • CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-...
  • CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YLJMETHYL-4-METHYLBENZE
  • CIS·[2-(2,4-DICHLOROPHENYL)-2-(TH-IMIDAZCL-1-YLMETHYL)-1,3-DIOXOLAN-4-YLJMETHYL-4-METHYLBENZE
  • cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methanolp-toluenesulfonate
  • 134071-44-6
  • 124071-44-6
  • C21H20Cl2N2O5S
  • Aromatics
  • Intermediates & Fine Chemicals