STM2457

Product Name: STM2457
CAS No.: 2499663-01-1
Chemical Name: STM2457
Synonyms: STM2457;STM2457 ，S9870;STM2457, 10 mM in DMSO;leukaemia,Apoptosis,cancer,STM-2457,autoimmune diseases,STM2457,inhibit,STM 2457,myeloid,Inhibitor;N-((6-(((Cyclohexylmethyl)amino)methyl)imidazo[1,2-a]pyridin-2-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide;4H-Pyrido[1,2-a]pyrimidine-2-carboxamide, N-[[6-[[(cyclohexylmethyl)amino]methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxo-;4-Oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid {6-[(cyclohexylmethyl-amino)-methyl]-imidazo[1,2-a]pyridin-2-ylmethyl}-amide;N - (6- (((cyclohexylmethyl) amino) methyl) imidazolo [1,2-a] pyridin-2-yl) methyl) -4-oxo-4H-pyridino [1,2-a] pyrimidin-2-formamide
CBNumber: CB28670993
Molecular Formula: C25H28N6O2
Formula Weight: 444.53
MOL File: 2499663-01-1.mol

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STM2457 Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 270 mg/mL
form: A solid
pka: 13.74±0.20(Predicted)
color: White to yellow
InChIKey: OBERVORNENYOLE-UHFFFAOYSA-N
SMILES: C12C=CC=CN1C(=O)C=C(C(NCC1=CN3C(=N1)C=CC(CNCC1CCCCC1)=C3)=O)N=2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3360
Product name: STM2457
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $84.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3360
Product name: STM2457
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $273.6
Updated: 2025/07/31

DC Chemicals

Product number: 028229
Product name: STM2457
Packaging: 002
Price: $280
Updated: 2021/12/16

DC Chemicals

Product number: 028229
Product name: STM2457
Packaging: 003
Price: $400
Updated: 2021/12/16

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STM2457 Chemical Properties,Usage,Production

Uses

STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML)[1][2].

Definition

ChEBI: STM2457 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid with the primary amino group of 1-[2-(aminomethyl)imidazo[1,2-a]pyridin-6-yl]-N-(cyclohexylmethyl)methanamine. It is a highly potent and selective first-in-class small molecule inhibitor of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity and exhibits anti-leukaemic activity. It has a role as an EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is an imidazopyridine, a secondary carboxamide, a secondary amino compound and a pyridopyrimidine.

Biological Activity

STM2457 is a potent and highly selective SAM-binding site METTL3 (MT-A70) m6A methyltransferase inhibitor (IC50 = 16.9 nM, Kd = 1.4 nM by SPR, using METTL3-METTL14 complex; no potency toward other RNA/DNA/protein methyltransferases or 486 kinases). STM2457 selectively inhibits human AML proliferation (IC50 = 0.6-10.3 μM) and the clonogenic potential of primary mouse AML, but not normal mouse haematopoietic stem/progenitor or human cord blood CD34+ cells. STM2457 impairs the expansion of AML patient-derived xenografts in mice in vivo (50 mg/kg i.p.) and significantly prolongs the animalμs lifespan. STM2457 is also reported to restrict β-coronavirus replication and spread.

References

[1] Wesley Peter Blackaby, et al. Mettl3 inhibitory compounds. WO2020201773A1.
[2] Eliza Yankova, et al. Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 2021 Apr 26. DOI:10.1038/s41586-021-03536-w

STM2457 Preparation Products And Raw materials

Raw materials

Preparation Products

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STM2457 Suppliers

China 70 United States 6 Global 76

Jinan Jiuli Biotechnology Co. , Ltd.

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2499663-01-1, STM2457Related Search:

4H-Pyrido[1,2-a]pyrimidine-2-carboxamide, N-[[6-[[(cyclohexylmethyl)amino]methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxo-

4-Oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid {6-[(cyclohexylmethyl-amino)-methyl]-imidazo[1,2-a]pyridin-2-ylmethyl}-amide

STM2457

leukaemia,Apoptosis,cancer,STM-2457,autoimmune diseases,STM2457,inhibit,STM 2457,myeloid,Inhibitor

N-((6-(((Cyclohexylmethyl)amino)methyl)imidazo[1,2-a]pyridin-2-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

N - (6- (((cyclohexylmethyl) amino) methyl) imidazolo [1,2-a] pyridin-2-yl) methyl) -4-oxo-4H-pyridino [1,2-a] pyrimidin-2-formamide

STM2457, 10 mM in DMSO

STM2457 ，S9870

2499663-01-1