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Befloxatone

Product Name
Befloxatone
CAS No.
134564-82-2
Chemical Name
Befloxatone
Synonyms
503;MD-370;MD370503;MD-370503;MD 370503;Befloxatone;(R)-5-(methoxymethyl)-3-(4-((R)-4,4,4-trifluoro-3-hydroxybutoxy)phenyl)oxazolidin-2-one;2-Oxazolidinone, 5-(methoxymethyl)-3-[4-[(3R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl]-, (5R)-
CBNumber
CB2874979
Molecular Formula
C15H18F3NO5
Formula Weight
349.3
MOL File
134564-82-2.mol
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Befloxatone Property

Melting point:
101°
alpha 
D20 -11.5° (c = 1 in methylene chloride)
Boiling point:
447.3±45.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
pka
12.13±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0010777
Product name
BEFLOXATONE
Purity
95.00%
Packaging
5MG
Price
$501.2
Updated
2021/12/16
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Befloxatone Chemical Properties,Usage,Production

Uses

Befloxatone is a selective and reversible inhibitor of monoamine oxidase A. A third line agent for the treatment of resistant depression.

in vivo

Befloxatone (0.75 mg/kg; i.p.; single dose) increases tissue levels of monoamines and decreases levels of their deaminating metabolites in rats[1].
Befloxatone (1 mg/kg; i.p.; single dose) induces elevated levels of dopamine and corticonorepinephrine in the extracellular striatum of rats, but not elevates levels of corticoserotonin[1].
Befloxatone (0.03-0.3 mg/kg; p.o.; single dose) effectively inhibits the firing rate of serotonergic neurons and partially reduces the firing of norepinephric neurons, but had no effect on the firing of dopaminergic neurons in rats[1].
Befloxatone (1.5 mg/kg; p.o.; single dose) does not enhance the pressor effect of the central active dose of oral tyramine and has a broad safety profile in rats[1].

IC 50

MAO-A: 4 nM (IC50); MAO-B: 300 nM (IC50)

Befloxatone Preparation Products And Raw materials

Raw materials

Preparation Products

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Befloxatone Suppliers

China 3 India 1 United States 3 Global 7
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29423
Advantage
58
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
Advantage
58

134564-82-2, BefloxatoneRelated Search:

(R)-5-(HYDROXYMETHYL)-3-METHYLOXAZOLIDIN-2-ONE 5-HYDROXYMETHYL-3-(4-METHOXYPHENYL)-2-OXAZOLIDINONE METHYL N-(4-METHOXYPHENYL)CARBAMATE (R)-5-(HYDROXYMETHYL)-3-PHENYLOXAZOLIDIN-2-ONE Befloxatone (R)-5-METHOXYMETHYL-2-OXAZOLIDINONE 3-PHENYL-2-OXAZOLIDINONE (4-METHOXY-PHENYL)-CARBAMIC ACID ETHYL ESTER (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL

  • Befloxatone
  • (R)-5-(methoxymethyl)-3-(4-((R)-4,4,4-trifluoro-3-hydroxybutoxy)phenyl)oxazolidin-2-one
  • 2-Oxazolidinone, 5-(methoxymethyl)-3-[4-[(3R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl]-, (5R)-
  • 503
  • MD 370503
  • MD-370
  • MD370503
  • MD-370503
  • 134564-82-2
  • C15H18F3NO5