Penbutolol

Product Name: Penbutolol
CAS No.: 38363-40-5
Chemical Name: Penbutolol
Synonyms: C07416;HOE 893;HOE 893D;Betapressin;l-Penbutolol;Levopenbutol;Levopenbutolol;(S)-Penbutolol;(-)-Penbutolol;(-)-(S)-Penbutolol
CBNumber: CB2875284
Molecular Formula: C18H29NO2
Formula Weight: 291.43
MOL File: 38363-40-5.mol

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Penbutolol Property

Melting point:: 68-72°
alpha: 20D -11.5° (c = 1 in methanol)
Boiling point:: 433.43°C (rough estimate)
Density: 1.0344 (rough estimate)
refractive index: 1.5000 (estimate)
pka: 9.3 (1.5 mmol/l in 25% ethanol)
color: Crystals
Water Solubility: 7g/L(room temperature)

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Safety

Toxicity: LD50 oral in rabbit: 300mg/kg

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Hazard and Precautionary Statements (GHS)

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Penbutolol Chemical Properties,Usage,Production

Originator

Betapressin, Hoechst , W. Germany ,1980

Uses

Anti-adrenergic (β-receptor).

Definition

ChEBI: Penbutolol is a member of ethanolamines.

Manufacturing Process

21.8 g (0.1 mol) of 1,2-epoxy-3-(2'-cyclopentylphenoxy)propane, boiling at 113°C to 115°C/0.2 mm Hg (prepared from 2-cyclopentylphenol and epichlorhydrin in the presence of alkali) were dissolved in 250 ml of ethanol; to this solution, there were added dropwise, while stirring.8.9 g (0.15 mol) of t-butylamine. The reaction mixture was stirred for 2 hours at 60°C and then the solvent and the excess t-butylamine were removed by distillation. The residue which had been purified via the aqueous hydrochloride, crystallized, after removal of the ether by evaporation, upon rubbing or inoculation and yielded, after recrystallization from n-heptane, the 1-t-butylamino-2-hydroxy3-(2'-cyclopentylphenoxy)propane which was found to melt at 69°C to 70°C.

brand name

Levatol(Schwarz Pharma).

Therapeutic Function

Beta-adrenergic blocker

Safety Profile

Poison by ingestion and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Penbutolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Penbutolol Suppliers

China 7 India 1 United Kingdom 1 United States 9 Global 18

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38363-40-5, PenbutololRelated Search:

Felodipine Bisoprolol (+)-(R)-Penbutolol,(R)-Penbutolol,d-Penbutolol PENBUTOLOL IMPURITY A PENBUTOLOL SULFATE USP(CRM STANDARD) PENBUTOLOL IMPURITY A(2S)-1-[2-(CYCLOPENT-1-ENYL)PHENOXY]-3-[(1,1-DIMETHYLETHYL)AMINO]PROPAN-2-OL EPP(CRM STANDARD) PENBUTOLOL SULPHATE EPP(CRM STANDARD) PENBUTOLOL SULPHATE PENBUTOLOL SULFATE (200 MG)

(-)-(S)-Penbutolol

(S)-Penbutolol

2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2S)- (9CI)

2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (S)-

Betapressin

HOE 893

HOE 893D

Levopenbutolol

l-Penbutolol

C07416

2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2S)-

Levopenbutol

(-)-Penbutolol

38363-40-5