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Nylidrin

Product Name
Nylidrin
CAS No.
447-41-6
Chemical Name
Nylidrin
Synonyms
Buphenin;Nylidrin;buphenine;Nylidrine;DILATAL(NYLIDRIN;Nylidrin USP/EP/BP;4-(1-Hydroxy-2-((4-phenylbutan-2-yl)amino)propyl)phenol;1-(4-hydroxyphenyl)-2-(1-methyl-3-phenylpropylamino)propan-1-ol;4-Hydroxy-α-[1-(1-methyl-3-phenylpropylamino)ethyl]benzyl alcohol;1-(4-Hydroxyphenyl)-2-[(1-methyl-3-phenylpropyl)amino]-1-propanol
CBNumber
CB2875325
Molecular Formula
C19H25NO2
Formula Weight
299.4073
MOL File
447-41-6.mol
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Nylidrin Property

Melting point:
111-112°
Boiling point:
476.0±40.0 °C(Predicted)
Density 
1.101±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
form 
A crystalline solid
pka
9.96±0.26(Predicted)
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Safety

Hazardous Substances Data
447-41-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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Nylidrin Chemical Properties,Usage,Production

Originator

Arlidin,U.S.V. ,US,1955

Uses

Buphenin (Nylidrin), is shown to be an effective inhibitor of IgE-mediated release of histamine from human basophils, and thus can be used as antiallergic agent. It is also one of the FDA approved drug as Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP).

Definition

ChEBI: 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol is an alkylbenzene.

Manufacturing Process

8 grams of the hydrobromide of 1-(p-benzoxyphenyl)-2-(α-methyl-γ-phenylpropylamino)-propanone-(1) were obtained by heating equivalent quantities of p-benzoxy-α-bromopropiophenone and 1-phenyl-3-amino-butane for an hour on the water bath in the absence of solvents. The product was purified by twice boiling with five times the quantity of acetic acid and filtration at 80°C, then shaken in contact with hydrogen with 0.8 gram of Raney nickel in 70 cc of pure methanol containing 0.96 gram (corresponding to 1 mol) of KOH. After 4 hours 2 mols of hydrogen had been taken up and the solution was filtered from the catalyst, evaporated in vacuo, and the residue triturated first with water to remove potassium bromide and then with methanol to remove potassium bromide. 3.7 grams (72% of the theoretical yield) of the compound specified, melting at 110° to 112°C, were obtained, as described in US Patent 2,661,373.

Therapeutic Function

Vasodilator

Nylidrin Preparation Products And Raw materials

Raw materials

Preparation Products

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Nylidrin Suppliers

Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
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China
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8065
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58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
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58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
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6973
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58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
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China
ProdList
10007
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TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24648
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Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
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China
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11974
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Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
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68144
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SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel
+8613817748580
Fax
021-50175322
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cooperation@kean-chem.com
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China
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40066
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Jilin Chinese Academy of Sciences-yanshen Technology
Tel
+undefined18143011203
Email
info@chemextension.com
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China
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42056
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58
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+undefined18621343501
Email
product@acmec-e.com
Country
China
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33338
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58

447-41-6, NylidrinRelated Search:


  • 1-(4-hydroxyphenyl)-2-(1-methyl-3-phenylpropylamino)propan-1-ol
  • buphenine
  • Nylidrin
  • Nylidrine
  • DILATAL(NYLIDRIN
  • 1-(4-Hydroxyphenyl)-2-[(1-methyl-3-phenylpropyl)amino]-1-propanol
  • 4-Hydroxy-α-[1-(1-methyl-3-phenylpropylamino)ethyl]benzyl alcohol
  • p-Hydroxy-α-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzenemethanol
  • Buphenin
  • Nylidrin USP/EP/BP
  • 4-(1-Hydroxy-2-((4-phenylbutan-2-yl)amino)propyl)phenol
  • Benzenemethanol, 4-hydroxy-α-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-
  • 447-41-6
  • C19H25NO2
  • Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals