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Muzolimine

Product Name
Muzolimine
CAS No.
55294-15-0
Chemical Name
Muzolimine
Synonyms
Edrul;Muzolimine;BAY-g-2821;Muzolimina;Muzoliminum;5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one;3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one;3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one;3H-Pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
CBNumber
CB2875411
Molecular Formula
C11H11Cl2N3O
Formula Weight
272.13
MOL File
55294-15-0.mol
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Muzolimine Property

Melting point:
127-129°
Boiling point:
401.4±55.0 °C(Predicted)
Density 
1.5374 (rough estimate)
refractive index 
1.5500 (estimate)
pka
3.30±0.50(Predicted)
form 
Solid
color 
Light yellow to yellow
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Safety

Toxicity
LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0012000
Product name
MUZOLIMINE
Purity
95.00%
Packaging
5MG
Price
$502.9
Updated
2021/12/16
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Muzolimine Chemical Properties,Usage,Production

Description

Muzolimine is a structurally novel, pyrazolone diuretic with a high-ceiling profile. It is somewhat slower in onset than furosemide, but has a more prolonged effect, similar to the thiazides. Muzolimine has been shown to be effective in edema of cardiac, hepatic and renal origin. It also appears to be effective as an antihypertensive agent.

Originator

Bayer (W. Germany)

Uses

Diuretic; antihypertensive.

Definition

ChEBI: Muzolimine is a dichlorobenzene.

Manufacturing Process

41 g of α-methyl-3,4-dichlorobenzylhydrazine, dissolved in absolute ethanol, were added dropwise to a solution of 31.8 g of β-amino-β-ethoxyacrylic acid ethyl ester and 1.5 g of p-toluenesulfonic acid in 150 ml of ethanol at room temperature under nitrogen gas. After stirring for 2 hours and standing overnight, the reaction solution was concentrated as far as possible on a rotary evaporator. The residue which remained was dissolved in 2 N sodium hydroxide solution. Any unconverted starting products or by-products were extracted with ether. The aqueous phase was then brought to pH 5 with acetic acid. The oil thereby produced was taken up in methylene chloride and the organic phase was dried over Na2SO4. After evaporating off the solvent, the reaction product crystallized out. It was recrystallized from methanol; melting point 127°C to 129°C; yield 21 g (38.5% of theory).

brand name

EDRUL

Therapeutic Function

Diuretic

World Health Organization (WHO)

Reports of neurological adverse effects, including paraesthesiae and paralyses, associated with prolonged use of high dosages of muzolimine, were received shortly after its introduction in 1984.

Muzolimine Preparation Products And Raw materials

Raw materials

Preparation Products

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Muzolimine Suppliers

TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30

55294-15-0, MuzolimineRelated Search:


  • 3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one
  • BAY-g-2821
  • Edrul
  • 3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one
  • Muzolimine
  • 3H-Pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
  • Muzolimina
  • Muzoliminum
  • 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one
  • 55294-15-0