ChemicalBook > CAS DataBase List > (R)-2-(2-Chlorophenyl)pyrrolidine

(R)-2-(2-Chlorophenyl)pyrrolidine

Product Name
(R)-2-(2-Chlorophenyl)pyrrolidine
CAS No.
823188-58-5
Chemical Name
(R)-2-(2-Chlorophenyl)pyrrolidine
Synonyms
(R)-2-(2-Chlorophenyl)pyrrolidine;(2R)-2-(2-chlorophenyl)pyrrolidine;Pyrrolidine,2-(2-chlorophenyl)-, (2R)-
CBNumber
CB2875729
Molecular Formula
C10H12ClN
Formula Weight
181.66
MOL File
823188-58-5.mol
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(R)-2-(2-Chlorophenyl)pyrrolidine Property

Boiling point:
254.1±33.0 °C(Predicted)
Density 
1.129±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
9.45±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC151298
Product name
(R)-2-(2-Chlorophenyl)pyrrolidine
Packaging
250mg
Price
$267.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151298
Product name
(R)-2-(2-Chlorophenyl)pyrrolidine
Packaging
500mg
Price
$465
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0038887
Product name
(R)-2-(2-CHLOROPHENYL)PYRROLIDINE
Purity
95.00%
Packaging
5MG
Price
$505.21
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151298
Product name
(R)-2-(2-Chlorophenyl)pyrrolidine
Packaging
50mg
Price
$77
Updated
2021/12/16
Activate Scientific
Product number
AS8672
Product name
(R)-2-(2-Chlorophenyl)pyrrolidine
Purity
95+% ee
Packaging
1g
Price
$729
Updated
2021/12/16
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(R)-2-(2-Chlorophenyl)pyrrolidine Chemical Properties,Usage,Production

Chemical Properties

Flashing point: 107.5 °C . Vapour pressure: 0.0176mmHg at 25°C. (R)-2-(2-Chlorophenyl)pyrrolidine is a chiral molecule whose optical isomer is (S)-2-(2-Chlorophenyl)pyrrolidine.

Physical properties

A colorless crystal

Uses

(R)-2-(2-Chlorophenyl)pyrrolidine can be used as an intermediate for organic synthesis.

Synthesis

To a dry Schlenk flask under nitrogen is added 0.540 g of (R, R)- (+)-ETHYLENE-1, 2- bis (N5-4, 5,6, 7-TETRAHYDRO-L-INDENYL) titanium difluoride and 120 mL of dry THF. To this solution are added under nitrogen in the following order: 2- (2-chlorophenyl)-pyrroline (15 g), phenylsilane (15 g), pyrrolidine (0.48 mL), and MeOH (0.24 mL). The solution is stirred at RT for 48 h, then the mixture is diluted with 350 mL of diethylether and carefully added with vigorous stirring to 1200 mL of 1 M HCI. The aqueous layer is separated and extracted with three portions of diethyl ether (300 mL each). The aqueous layer is made basic with 3M NAOH and extracted with 5 portions of diethyl ether (200 mL each). The combined ether layers are dried over magnesium sulfate and concentrated in vacuo. The residue is purified by vacuum transfer to give (R)-2-(2-Chlorophenyl)pyrrolidine (15 g, 93%) as a colorless oil.

(R)-2-(2-Chlorophenyl)pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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823188-58-5, (R)-2-(2-Chlorophenyl)pyrrolidineRelated Search:

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  • (2R)-2-(2-chlorophenyl)pyrrolidine
  • Pyrrolidine,2-(2-chlorophenyl)-, (2R)-
  • (R)-2-(2-Chlorophenyl)pyrrolidine
  • 823188-58-5
  • API intermediates