nifurtoinol
- Product Name
- nifurtoinol
- CAS No.
- 1088-92-2
- Chemical Name
- nifurtoinol
- Synonyms
- urfadyn;Urfurine;nifurtoinol;3-(Hydroxymethyl)-1-[[(5-nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione;2,4-Imidazolidinedione, 3-(hydroxymethyl)-1-[[(5-nitro-2-furanyl)methylene]amino]-;3-(hydroxymethyl)-1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidine-2,4-dione
- CBNumber
- CB2876175
- Molecular Formula
- C9H8N4O6
- Formula Weight
- 268.18
- MOL File
- 1088-92-2.mol
nifurtoinol Property
- Melting point:
- 258 °C (decomp)
- Boiling point:
- 411.35°C (rough estimate)
- Density
- 1.5401 (rough estimate)
- refractive index
- 1.6590 (estimate)
- pka
- 13.41±0.10(Predicted)
- Water Solubility
- 0.33g/L(22 ºC)
N-Bromosuccinimide Price
- Product number
- CHM1001843
- Product name
- 3-(HYDROXYMETHYL)-1-[[(E)-(5-NITRO-2-FURYL)METHYLIDENE]AMINO]-2,4-IMIDAZOLIDINEDIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.04
- Updated
- 2021/12/16
nifurtoinol Chemical Properties,Usage,Production
Originator
Urfadyne,Zambon,W. Germany,1969
Definition
ChEBI: An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group and at position 3 by a hydroxymethyl group.
Manufacturing Process
Three liters of 5% formaldehyde solution (2,625 cc water and 375 cc 40% formalin) containing 50 g of nitrofurantoin is refluxed for about 5 minutes, then filtered hot and cooled. The crystallized product is filtered and washed with 1% formaldehyde solution. It is air dried and then further dried at 65°C. There is obtained 33 g of 3-hydroxymethyl-1-(5-nitrofurfurylideneamino) hydantoin.
Therapeutic Function
Antibacterial
Pharmaceutical Applications
The hydroxymethyl derivative of nitrofurantoin, formulated for oral administration. The activity is similar to that of nitrofurantoin. Little is known about the pharmacokinetic behavior. It is said to be more rapidly absorbed than nitrofurantoin and excreted into the urine to a greater extent. Available in some countries in continental Europe.
nifurtoinol Preparation Products And Raw materials
Raw materials
Preparation Products
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