2-chloro-6-methoxypyridin-3-amine
- Product Name
- 2-chloro-6-methoxypyridin-3-amine
- CAS No.
- 34392-85-3
- Chemical Name
- 2-chloro-6-methoxypyridin-3-amine
- Synonyms
- 2-Chloro-6-methoxy-3-pyridinamine;2-chloro-6-methoxypyridin-3-amine;3-Pyridinamine,2-chloro-6-methoxy-;2-Chloro-6-methoxy-pyridin-3-ylamine;2-Chloro-6-methoxypyridin-3-amine, HCl;3-Amino-2-chloro-6-methoxypyridine,HCl;Pyridine,3-amino-2-chloro-6-methoxy- (8CI)
- CBNumber
- CB2880813
- Molecular Formula
- C6H7ClN2O
- Formula Weight
- 158.59
- MOL File
- 34392-85-3.mol
2-chloro-6-methoxypyridin-3-amine Property
- Melting point:
- 46-50 °C
- Boiling point:
- 276.7±35.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.68±0.10(Predicted)
- Appearance
- Brown to reddish brown Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/37/39
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A595468
- Product name
- 3-Amino-2-chloro-6-methoxypyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA55775
- Product name
- 3-Amino-2-chloro-6-methoxypyridine hydrochloride
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 081301
- Product name
- 2-Chloro-6-methoxypyridin-3-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- 081301
- Product name
- 2-Chloro-6-methoxypyridin-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 4H56-5-1W
- Product name
- 2-Chloro-6-methoxypyridin-3-amine
- Purity
- 98%
- Packaging
- 5G
- Price
- $95
- Updated
- 2021/12/16
2-chloro-6-methoxypyridin-3-amine Chemical Properties,Usage,Production
Synthesis
38533-61-8
34392-85-3
The general procedure for the synthesis of 2-chloro-3-amino-6-methoxypyridine using 2-chloro-6-methoxy-3-nitropyridine as starting material was as follows: tin(II) chloride dihydrate (6 g, 26.52 mmol) was added to a solution of 2-chloro-6-methoxy-3-nitropyridine (1 g, 5.30 mmol) in ethyl acetate (15 mL), and the resulting suspension was heated at 70 °C with stirring for 1 hour. The resulting suspension was heated with stirring for 1 hour at 70°C. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 9-10 with saturated aqueous sodium carbonate solution, followed by extraction with ethyl acetate (3 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with ethyl acetate:heptane (3:7, v/v) as eluent to afford the target compound 2-chloro-3-amino-6-methoxypyridine as a light yellow oil (600 mg, 72% yield). The product was confirmed by mass spectrometry (ESI), m/z: 159 ([M+H]+).
References
[1] Journal of Organic Chemistry, 2011, vol. 76, # 23, p. 9841 - 9844
[2] Organic Letters, 2016, vol. 18, # 11, p. 2774 - 2776
[3] Patent: WO2007/39563, 2007, A1. Location in patent: Page/Page column 26
[4] Patent: US2007/112019, 2007, A1. Location in patent: Page/Page column 13/2
[5] Patent: US2003/236287, 2003, A1. Location in patent: Page 40
2-chloro-6-methoxypyridin-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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