parsalmide

parsalmide Property

Melting point:

83-85℃

Boiling point:

389.31°C (rough estimate)

Density 

1.107

refractive index 

1.5500 (estimate)

pka

pKa (aq soln, 20°) 4.6 ±0.03

Hazard and Precautionary Statements (GHS)

parsalmide Chemical Properties,Usage,Production

Originator

Parsalmide,Shanghai Lansheng Corporation

Definition

ChEBI: Parsalmide is a member of benzamides.

Manufacturing Process

5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the presence of sodium hydroxide
5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.

Therapeutic Function

Muscle relaxant, Antiinflammatory, Analgesic