apovincamine
- Product Name
- apovincamine
- CAS No.
- 4880-92-6
- Chemical Name
- apovincamine
- Synonyms
- Apovincamina;apovincamine;Apovincaminum;Vinpocetine-2;Unii-504R182zx7;Einecs 225-491-0;cis-ApovincaMine;(+)-trans-Cavinton;(+)-trans-Cavinton;Vincamine Impurity D
- CBNumber
- CB2890058
- Molecular Formula
- C21H24N2O2
- Formula Weight
- 336.43
- MOL File
- 4880-92-6.mol
apovincamine Property
- Melting point:
- 160-162℃
- Boiling point:
- 405.7±45.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 7.82±0.60(Predicted)
- color
- Off-White to Pale Grey
Safety
- HS Code
- 2939800000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0000591
- Product name
- Vinpocetine impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000591
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 1714620
- Product name
- Vinpocetine impurity B
- Packaging
- 30mg
- Price
- $1290
- Updated
- 2024/03/01
- Product number
- A729245
- Product name
- cis-Apovincamine
- Packaging
- 10mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- PXT0004644
- Product name
- APOVINCAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.54
- Updated
- 2021/12/16
apovincamine Chemical Properties,Usage,Production
Originator
Apovincamine,GC Promochem
Uses
cis-Apovincamine (Vinpocetine USP Related Compound B), is a vinca alkaloid and a chemical precursor of Vinpocetine (V332500), a derivative of Vincamine with vasodilating activity. Vasodilator (cerebral).
Definition
ChEBI: Apovincamine is an alkaloid.
Manufacturing Process
Apovincamine is semisynthethetic derivative of (+)-vincamine. Vincamine is
alkaloid of Vinca minor. Alcoloid of Tabernaemontana rigida (Apocynaceae)
also is used as raw material for preparing of apovincamine. (+)- Vincamine
was transformed into oxime ester by reaction with NaNO2 in acetic acid at 0°C
-(+/-)-methyl-3-((12bR)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-
a]quinolizin-1-yl)-2-(hydroxyimino)propanoate, which was resolved on the
isomers with dibenzoyl D-tartratic acid. (-)-Methyl 3-((12bR)-1-ethyl-
1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl)-2-
(hydroxyimino)propanoate was re-crystallized from methanol to afford (-)-
methyloxime ester, MP: 195°C.
2 g of above oxime methyl ester was heated in mixture of methanol (37.5 ml)
and conc. H2SO4 (13.5 ml) on water bath for 1 hour. The solution was poured
into ice-water (80 ml), basified with conc. NH4OH to pH 9, and extracted with
CH2Cl2 (3x20 ml). The combined extracts were dried (MgSO4), filtered,
evaporated in vacuum and the residue was re-crystallized from MeOH (5 ml)
to yield 1.32 g (72.5%) of (+)-apovincamine, MP: 160°-162°C.
Therapeutic Function
Vasodilator
apovincamine Preparation Products And Raw materials
Raw materials
Preparation Products
apovincamine Suppliers
- Tel
- --
- Fax
- --
- sales@whytechemicals.co.uk
- Country
- United Kingdom
- ProdList
- 3748
- Advantage
- 50
View Lastest Price from apovincamine manufacturers
- Product
- apovincamine 4880-92-6
- Price
- US $1.00-2.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-08-08