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Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]-

Product Name
Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]-
CAS No.
2412270-22-3
Chemical Name
Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]-
Synonyms
CA77.1;CA77.1 [CMA Activator;CA77.1, 10 mM in DMSO;N-(4-(6-Chloroquinoxalin-2-yl)phenyl)acetamide;Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]-;Autophagy,CA-77.1,CMA,Inhibitor,LAMP2A,CA77.1,inhibit,alzheimer's?disease,derivative,neuropathology,KFERQ
CBNumber
CB28903798
Molecular Formula
C16H12ClN3O
Formula Weight
297.74
MOL File
2412270-22-3.mol
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Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]- Property

Boiling point:
537.1±50.0 °C(Predicted)
Density 
1.351±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 5 mg/mL (16.79 mM; ultrasonic and warming and heat to 60°C)|Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
form 
A solid
pka
14.43±0.70(Predicted)
color 
Off-white to light yellow
InChI
1S/C16H12ClN3O/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9H,1H3,(H,19,21)
InChIKey
ZQXMPDVGBWOTBY-UHFFFAOYSA-N
SMILES
Clc1cc2ncc(nc2cc1)c3ccc(cc3)NC(=O)C
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences
Product number
AG-CR1-0165-M005
Product name
CA77.1[CMAActivator]
Purity
≥98%(HPLC)
Packaging
5mg
Price
$80
Updated
2021/12/16
DC Chemicals
Product number
028226
Product name
CA77.1
Packaging
001
Price
$500
Updated
2021/12/16
DC Chemicals
Product number
028226
Product name
CA77.1
Packaging
002
Price
$900
Updated
2021/12/16
DC Chemicals
Product number
028226
Product name
CA77.1
Packaging
003
Price
$1800
Updated
2021/12/16
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Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]- Chemical Properties,Usage,Production

Uses

CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A inlysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer'sdisease research[1].

Biological Activity

CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 and can increase the expression of the lysosomal receptor LAMP2A in lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer’s disease research[1]. CA77.1 (0-30 μM; 16 hours) activates CMA in a dose-and time-dependent manner to NIH 3T3 cells stably expressing the KFERQ-PS-Dendra reporter. The CMA activity is quantified as the average of fluorescent puncta per cell[1].CA77.1 (20 μM; 6 hours) does not alter on LC3-II expression, and does not effects autophagic flux in NIH 3T3 cells[1]. CA77.1 (oral gavage; 10 mg/kg;single dose) demonstrates brain penetrance with favorable pharmacokinetics. The Cmax, AUClast, Tmax and T1/2 are 3534 ng/g, 8338 h*ng/g, 1 hour and 1.89 hour, respectively[1].CA77.1 (oral gavage; 30 mg/kg; 6 months) normalizes the previously described locomotor hyperactivity of PS19 mice to control levels. And it reduces the levels and number of neurons containing pathogenic tau conformations in the hippocampus, amygdala, and piriform cortex. And the higher number of microglial cells and presence of large Iba1-positive cells with rod-like dystrophic morphology in vehicle-treated PS19 mice are reduced upon CA77.1 treatment[1].

in vivo

CA77.1 (oral gavage; 10 mg/kg;single dose) demonstrates brain penetrance with favorable pharmacokinetics. The Cmax, AUClast, Tmax and T1/2 are 3534 ng/g, 8338 h*ng/g, 1 hour and 1.89 hour, respectively[1].CA77.1 (oral gavage; 30 mg/kg; 6 months) normalizes the previously described locomotor hyperactivity of PS19 mice to control levels. And it reduces the levels and number of neurons containing pathogenic tau conformations in the hippocampus, amygdala, and piriform cortex. And the higher number of microglial cells and presence of large Iba1-positive cells with rod-like dystrophic morphology in vehicle-treated PS19 mice are reduced upon CA77.1 treatment[1].

Animal Model:9-month-old CTR or PS19 mice[1]
Dosage:30 mg/kg
Administration:Oral gavage; 30 mg/kg; 6 months
Result:Improved behavior and neuropathology in a mouse model of frontotemporal-dementia-related proteotoxicity.

References

[1]. Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell. 2021 May 13;184(10):2696-2714.e25.

Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]- Suppliers

China 38 United States 6 Global 44
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View Lastest Price from Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]- manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
CA77.1 2412270-22-3
Price
US $450.00/box
Min. Order
1box
Purity
98%
Supply Ability
10
Release date
2023-06-13

2412270-22-3, Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]-Related Search:


  • Acetamide, N-[4-(6-chloro-2-quinoxalinyl)phenyl]-
  • CA77.1
  • Autophagy,CA-77.1,CMA,Inhibitor,LAMP2A,CA77.1,inhibit,alzheimer's?disease,derivative,neuropathology,KFERQ
  • CA77.1 [CMA Activator
  • N-(4-(6-Chloroquinoxalin-2-yl)phenyl)acetamide
  • CA77.1, 10 mM in DMSO
  • 2412270-22-3