1-isopropylpiperidin-4-ol
- Product Name
- 1-isopropylpiperidin-4-ol
- CAS No.
- 5570-78-5
- Chemical Name
- 1-isopropylpiperidin-4-ol
- Synonyms
- 1-isopropylpiperidin-4-ol;1-propan-2-yl-4-piperidinol;4-Hydroxy-1-isopropylpiperidine;1-(1-Methylethyl)piperidin-4-ol;N-isopropyl-4-hydroxypiperidine;1-(1-Methylethyl)-4-piperidinol;4-Piperidinol,1-(1-Methylethyl)-;1-isopropylpiperidin-4-ol(SALTDATA: FREE)
- CBNumber
- CB2901527
- Molecular Formula
- C8H17NO
- Formula Weight
- 143.23
- MOL File
- 5570-78-5.mol
1-isopropylpiperidin-4-ol Property
- Boiling point:
- 227℃
- Density
- 0.976
- Flash point:
- 75℃
- storage temp.
- 2-8°C
- pka
- 14.88±0.20(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B451578
- Product name
- 1-Isopropylpiperidin-4-ol
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B451578
- Product name
- 1-Isopropylpiperidin-4-ol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR909302
- Product name
- 1-isopropylpiperidin-4-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $515
- Updated
- 2021/12/16
- Product number
- CHM0135436
- Product name
- 1-ISOPROPYLPIPERIDIN-4-OL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $867.12
- Updated
- 2021/12/16
- Product number
- CHM0135436
- Product name
- 1-ISOPROPYLPIPERIDIN-4-OL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1722.11
- Updated
- 2021/12/16
1-isopropylpiperidin-4-ol Chemical Properties,Usage,Production
Synthesis
5382-16-1
67-64-1
5570-78-5
The general procedure for the synthesis of 1-isopropyl-4-piperidinol from 4-hydroxypiperidine and acetone was as follows: a mixture of 4-hydroxypiperidine (10 g, 0.10 mol), acetone (21.8 mL, 0.30 mol), acetic acid (5.7 mL, 0.10 mol), and tetrahydrofuran (150 mL) was stirred in an ice bath for 15 minutes. Subsequently, sodium triacetoxyborohydride (31.3 g, 0.15 mol) was added in batches and stirring was continued for 10 minutes. The reaction mixture was gradually warmed up to room temperature, stirred for 10 minutes and then stirred at 40°C for 2.5 hours. After the reaction was completed, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in water (50 mL). The pH of the aqueous solution was adjusted to 9 with concentrated ammonia (0.88) and stirred continuously for 30 minutes. Next, the reaction mixture was extracted with ether (2 x 200 mL), the organic phases were combined, dried with anhydrous sodium sulfate and concentrated in vacuum to obtain a yellow oil. The oily substance was purified by silica gel column chromatography with the eluent ratio of dichloromethane: methanol: concentrated ammonia (0.88), which was tapered from 96:4:1 to 90:10:1, to give the title compound 1-isopropyl-4-piperidinol as a yellow oily substance in a yield quantified as 14.6 g. The product was purified by 1H-NMR (CDCl3, 400 MHz) and mass spectrometry (MS ES+ m/ z 144 [MH]+) to confirm the structure.
References
[1] Patent: EP1595881, 2005, A1. Location in patent: Page/Page column 64
[2] Patent: WO2007/52124, 2007, A1. Location in patent: Page/Page column 17
[3] Patent: WO2009/121812, 2009, A1. Location in patent: Page/Page column 69
[4] Patent: US2009/233910, 2009, A1. Location in patent: Page/Page column 57
1-isopropylpiperidin-4-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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