Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy-
- Product Name
- Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy-
- CAS No.
- 2243944-92-3
- Chemical Name
- Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy-
- Synonyms
- FTO-IN-1;UUN44923;Dac51 ，S9876;Dac51，UUN-44923;FTO-IN-1, 10 mM in DMSO;2-[[2,6-Dichloro-4-(3,5-dimethyl-4-pyrazolyl)phenyl]amino]-N-hydroxybenzamide;mass,cancer,FTO,associated,enzyme,inhibit,FTOIN1,fat,obesity,Inhibitor,FTO IN 1;2-((2,6-Dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)-N-hydroxybenzamide;Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy-
- CBNumber
- CB29028061
- Molecular Formula
- C18H16Cl2N4O2
- Formula Weight
- 391.25
- MOL File
- 2243944-92-3.mol
Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy- Property
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (197.91 mM);Water: Insoluble;Ethanol: Insoluble
- pka
- 8.72±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy- Chemical Properties,Usage,Production
Description
UUN44923 is a FTO inhibitor. UUN44923 may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS), type 2 diabetes (T2D), Alzheimer's diseases, breast cancers, small-cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like. UUN44923 was reported in WO 2018157843. This product has no formal name at the moment.
Uses
FTO-IN-1 is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μM. FTO-IN-1 can be used for the research of cancer[1].
References
[1] Yang C, et, al. 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof. WO2018157843A1.
Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy- Preparation Products And Raw materials
Raw materials
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