O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride
- Product Name
- O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride
- CAS No.
- 6138-47-2
- Chemical Name
- O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride
- Synonyms
- Liotironina;Liothyronine HCl;3,3',5-Triiodo-L-thyronineHCl;3,3',5-Triiodo-L-thyroninehydrochloride;O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride
- CBNumber
- CB2917577
- Molecular Formula
- C15H13ClI3NO4
- Formula Weight
- 687.43443
- MOL File
- 6138-47-2.mol
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride Property
- alpha
- D29.5 +21.5° (c = 4.75 in a mixture of 1 vol N HCl and 2 vols ethanol)
N-Bromosuccinimide Price
- Product number
- API0017115
- Product name
- LIOTHYRONINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.7
- Updated
- 2021/12/16
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride Chemical Properties,Usage,Production
Uses
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].
References
[1] Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. DOI:10.1016/0304-3835(94)90274-7
[2] Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. DOI:10.1006/bbrc.1993.2055
[3] Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. DOI:10.1016/j.bmc.2012.03.056
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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