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Cysteamine bitartrate

Product Name
Cysteamine bitartrate
CAS No.
27761-19-9
Chemical Name
Cysteamine bitartrate
Synonyms
Cystagon;CYSTEAMINE BITRATRATE;Cysteamine bitartrate;Mercaptamine bitartrate;(mercaptoethyl)ammonium hydrogen tartrate;2-Aminoethanethiol (2R,3R)-2,3-dihydroxysuccinate
CBNumber
CB2919995
Molecular Formula
C6H13NO6S
Formula Weight
227.23
MOL File
27761-19-9.mol
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Cysteamine bitartrate Property

storage temp. 
Store at -20°C
solubility 
DMSO: 45 mg/mL (198.03 mM);Ethanol: Insoluble
Water Solubility 
Water: 45 mg/mL (198.03 mM)
InChI
InChI=1/C4H6O6.C2H7NS/c5-1(3(7)8)2(6)4(9)10;3-1-2-4/h1-2,5-6H,(H,7,8)(H,9,10);4H,1-3H2/t1-,2-;/s3
InChIKey
NSKJTUFFDRENDM-RZHFEHKBNA-N
SMILES
C(N)CS.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:4,9,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0015192
Product name
CYSTEAMINE BITARTRATE
Purity
95.00%
Packaging
5MG
Price
$503.66
Updated
2021/12/16
DC Chemicals
Product number
DC9206
Product name
Cysteaminebitartrate
Purity
>98%
Packaging
1g
Price
$800
Updated
2021/12/16
DC Chemicals
Product number
DC9206
Product name
Cysteaminebitartrate
Purity
>98%
Packaging
100mg
Price
$300
Updated
2021/12/16
DC Chemicals
Product number
DC9206
Product name
Cysteaminebitartrate
Purity
>98%
Packaging
250mg
Price
$450
Updated
2021/12/16
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Cysteamine bitartrate Chemical Properties,Usage,Production

Description

Cysteamine bitartrate is an amino thiol and a byproduct of the cysteine degradation pathway that is an FDA-approved therapy for the treatment of nephropathic cystinosis to decrease the accumulation of lysosomal cystine (the disulfide-linked form of cysteine) by engaging in disulfide exchange. In addition, cysteamine bitartrate has been postulated to have broader antioxidant properties potentially related to a distinct role in increasing cysteine availability to support the biosynthesis of the potent antioxidant molecule glutathione[1].

References

[1] Sujay Guha. “Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease.” Human molecular genetics (2019): 1837–1852.
[2] Sabrina Klank. “Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients.” Pharmaceutics 15 7 (2023).

Uses

Cysteamine bitartrate (CAS# 27761-19-9) treatment of cystinosis and other metabolic and neurodegenerative diseases.

Mechanism of action

Cysteamine Bitartrate is an aminothiol salt used in the treatment of nephropathic cystinosis. Cysteamine bitartrate depletes cystine in lysosomes by reacting with cysteine and forming a mixed cysteine–cysteamine disulfide that can exit the lysosomes via lysine transporters. This prevents the accumulation of cystine crystals in the lysosomes of patients with cystinosis, which can cause considerable damage and eventual destruction of the cells, particularly in the kidneys[2].

Clinical Use

Currently, three different formulations of oral cysteamine bitartrate are available: immediate-release (IR-) cysteamine bitartrate (Cystagon, Mylan Pharmaceuticals, Canonsburg, PA and Recordati Pharma GmbH), delayed-release (DR-) enteric-coated cysteamine bitartrate, RP103 (Procysbi®, Horizon Pharma USA and Chiesi Farmaceutici S.p.A., Parma, Italy), and a third formulation in which cysteamine is encapsulated by a pharmacist for enteric release (EC-cysteamine). In Germany, this formulation was generated by the patient advocacy group due to the unbearable side effects of IR-cysteamine (Cystagon®). It was started as an alternative to Cystagon® before Procysbi® appeared on the market. Cysteamine bitartrate is filled into enteric-release capsules and sealed with a fluid. Having been used in clinical practice for many years, a delayed release effect has been described with fewer side effects than Cystagon®[2].

Cysteamine bitartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Cysteamine bitartrate Suppliers

Rushpharm Co.,Ltd.
Tel
025-66042949 15161141411
Fax
025-66042949
Email
2244332520@qq.com
Country
China
ProdList
55
Advantage
58
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2045
Advantage
56
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
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View Lastest Price from Cysteamine bitartrate manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
Cysteamine bitartrate 27761-19-9
Price
US $6.80-2.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-07-05

27761-19-9, Cysteamine bitartrateRelated Search:


  • (mercaptoethyl)ammonium hydrogen tartrate
  • Cysteamine bitartrate
  • Cystagon
  • CYSTEAMINE BITRATRATE
  • 2-Aminoethanethiol (2R,3R)-2,3-dihydroxysuccinate
  • Mercaptamine bitartrate
  • 27761-19-9
  • C4H6O6C2H7NS