aceprometazine Property

Boiling point:

490.1±45.0 °C(Predicted)

Density 

1.1075 (rough estimate)

refractive index 

1.5950 (estimate)

solubility 

Chloroform (Slightly), Methanol (Sparingly)

pka

8.93±0.50(Predicted)

form 

A liquid

Safety

Toxicity

LD50 orl-mus: 517 mg/kg AAREAV 21,543,64

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

aceprometazine Chemical Properties,Usage,Production

Originator

Aceprometazine ,ZYF Pharm Chemical

Uses

Acepromethazine is a phenothiazine derivative that is often used in combination with Meprobamate (M227750) for the treatment of sleep disorders.

Definition

ChEBI: A phenothiazine compound having an acetyl group at the 2-position and a 2-(dimethylamino)-1-propyl group at the 10-position.

Manufacturing Process

In a 1 liter flask, equipped with stirrer, thermometer and nitrogen inlet, 241.0 g of 2-acetylphenothiazine (1 mole) is dissolved in 300 ml of dry dimethylformamide. When the 2-acetylphenothiazine is almost completely soluble, to this solution is added 275 ml of a 4 N solution of 1-dimethylamino- 2-chloropropane in toluene.
The mixture is heated to 50°C and 26.0 g (1.08 moles) of sodium hydride is added portion-wise, maintaining the temperature at 50°-60°C. The addition should take about 1 h. The reaction is allowed to stir for 3 h at 50°-60°C. Any excess hydride is destroyed by the cautious addition of 10 ml methanol, and the reaction mix is poured into 800 ml of 20% acetic acid.
The toluene layer is separated and extracted with 150 ml of 20% acetic acid, and discarded. The acid solutions are combined and washed once with toluene. The toluene is discarded. Fresh toluene (200 ml) is added and caustic solution is added with cooling and stirring until the pH is 9 or above. The toluene layer is separated. The aqueous layer is extracted once more with 75 ml of toluene and discarded. The toluene extracts are combined, given a small water wash, and concentrated. The residue is distilled yielding 10-[2- (dimethylamino)propyl]-2-acetylphenothiazine.

Therapeutic Function

Neuroleptic, Antitussive

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion. A flammable liquid. Whenheated to decomposition it emits toxic vapors of NOx andSOx.