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tibezonium iodide

Product Name
tibezonium iodide
CAS No.
54663-47-7
Chemical Name
tibezonium iodide
Synonyms
Antoral;Nsc308905;Tibezonium;Rec 15-0691;Thiabenzazonium;tibezonium iodide;tibenzonium iodide;Diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide;N,N-Diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethanaminium iodide;diethyl-methyl-[2-[[2-(4-phenylsulfanylphenyl)-3H-1,5-benzodiazepin-4-yl]sulfanyl]ethyl]azanium:iodide
CBNumber
CB2931324
Molecular Formula
C28H32IN3S2
Formula Weight
601.60825
MOL File
54663-47-7.mol
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tibezonium iodide Property

Melting point:
162℃
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Safety

Toxicity
LD50 in mice, rats (mg/kg): 9000, >10000 orally; 42, 35 i.p. (Nardi)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T437300
Product name
TibezoniumIodide
Packaging
10mg
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012626
Product name
TIBEZONIUM IODIDE
Purity
95.00%
Packaging
5MG
Price
$500.78
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48959
Product name
TibezoniumIodide
Packaging
100mg
Price
$2400
Updated
2021/12/16
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tibezonium iodide Chemical Properties,Usage,Production

Originator

Antoral,Recordati,Italy,1977

Uses

Tibezonium Iodide is a possible inhibitor of Trypanosoma cruzi dihydrofolate reductase.

Manufacturing Process

4-Acetyldiphenylsulfide is reacted with carbon disulfide in an initial step to give 4-phenylthiobenzoyl dithioacetic acid. That, in turn, is reacted with o_x0002_phenylenediamine. A mixture of 3.6 g of the thus obtained 4-p-phenylthiophenyl-1,3-dihydro-2H- 1,5-benzodiazepine-2-thione, 0.50 g of 50% sodium hydride in oil and 200 ml of benzene is refluxed for 30 minutes, then a solution of 2.02 g of β- diethylaminoethyl chloride in 5 ml of benzene are added dropwise over 5 minutes.
The mixture is refluxed for 10 hours. The mixture is then cooled and filtered to separate the sodium chloride. The filtrate is evaporated to dryness in vacuo. The oily residue is dissolved in petroleum ether and the solution is filtered with charcoal. The solvent is evaporated in vacuo. The oily residue is heated to 50°C in vacuo (0.01 mm Hg) to remove the excess of β- diethylaminoethyl chloride.
This treatment is continued until the β-diethylaminoethyl chloride disappears(TLC). The oil is then dissolved in isopropanol and weakly acidified with HCl in propanol. The 2β-N-diethylaminoethylthio-4-p-phenylthiophenyl-3H-1,5- benzodiazepine HCl product crystallizes by addition of anhydrous ethyl ether to the solution. The crystals are filtered and recrystallized from ethyl acetate. Yield 3.65 g, melting point 150°C.
2.55 g of methyl iodide are added to a solution of 5.93 g of 2-β-Ndiethylaminoethylthio-4-phenylthiophenyl-3H-1,5-benzodiazepine in 100 ml of isopropanol. The mixture is kept at 20°C to 30°C for 60 hours. The crystals are then filtered. Yield 6.2 g, melting point 161°C.

Therapeutic Function

Antimicrobial

tibezonium iodide Preparation Products And Raw materials

Raw materials

Preparation Products

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tibezonium iodide Suppliers

LUCKY PHARMA CO., LIMITED
Tel
0571-86403260 86403970
Fax
0571-86403970
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lucky@lkbiology.com
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China
ProdList
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Capot Chemical Co.,Ltd.
Tel
571-85586718 +8613336195806
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sales@capotchem.com
Country
China
ProdList
29797
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Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
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2678564200@qq.com
Country
China
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17997
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Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418671
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34571
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CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49391
Advantage
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Wuhan Fengyao Tonghui Chemical Products Co. LTD
Tel
027-87466205 15377579727
Email
1228964013@qq.com
Country
China
ProdList
8561
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Coresyn Pharmatech Co., Ltd.
Tel
+86-571-86626709 +86-18157142896
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cbc@coresyn.com
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China
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9991
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54663-47-7, tibezonium iodideRelated Search:


  • tibezonium iodide
  • Tibezonium
  • tibenzonium iodide
  • Diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide
  • Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]-, iodide
  • Nsc308905
  • Thiabenzazonium
  • Antoral
  • N,N-Diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethanaminium iodide
  • Rec 15-0691
  • diethyl-methyl-[2-[[2-(4-phenylsulfanylphenyl)-3H-1,5-benzodiazepin-4-yl]sulfanyl]ethyl]azanium:iodide
  • 54663-47-7
  • C28H32N3S2I
  • C28H32IN3S2