Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate

Product Name: Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
CAS No.: 147118-39-6
Chemical Name: Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
Synonyms: ZD-6 ;D36-C(GLS);6(E)-heptenoate;5-Oxorosuvastatin Methyl ester;Rosuvastatin 5-Oxo Acid Methyl Ester;7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-Meth...;Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methy;Metamizole Sodium Impurity 4-d6（Metamizole Sodium EP Impurity D-d6）;(R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)-pyrimidin-5-yl)-3;(R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)-pyrimidin-5-yl)-3-hy
CBNumber: CB2947400
Molecular Formula: C23H28FN3O6S
Formula Weight: 493.55
MOL File: 147118-39-6.mol

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Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate Property

Melting point:: 103-107°C
Boiling point:: 701.7±70.0 °C(Predicted)
Density: 1.311
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.87±0.20(Predicted)
color: Pale Yellow to Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: O862005
Product name: 5-OxorosuvastatinMethylEster
Packaging: 25mg
Price: $95
Updated: 2021/12/16

TRC

Product number: O862005
Product name: 5-OxorosuvastatinMethylEster
Packaging: 100mg
Price: $135
Updated: 2021/12/16

TRC

Product number: O862005
Product name: 5-OxorosuvastatinMethylEster
Packaging: 250mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: B340
Product name: 5-Oxorosuvastatinmethylester
Packaging: 100mg
Price: $125
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0000956
Product name: METHYL 7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL]-(3R)-3-HYDROXY-5-OXO-(E)-6-HEPTENATE
Purity: 95.00%
Packaging: 25MG
Price: $288.75
Updated: 2021/12/16

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Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate Chemical Properties,Usage,Production

Uses

5-Oxorosuvastatin methyl ester is an intermediate in the synthesis of Rosuvasatatin (calcium salt: R700500), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that decreases high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations in the blood.

Synthesis

147118-38-5

147118-39-6

Under ice bath cooling conditions, 16 g of methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)-5-pyrimidinyl]-(3R)-tert-butyldimethylsilyloxy-5-oxo-(6E)-heptanoate (compound ii) was dissolved in 100 mL of acetonitrile. Subsequently, a 400 mL solution prepared from 48% hydrogen fluoride and acetonitrile at a volume ratio of 1:19 was slowly added dropwise. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1.5 hours. Upon completion of the reaction, the reaction mixture was neutralized with sodium bicarbonate solution and subsequently extracted with ether. The organic layer was washed with aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. Eventually, the residual ether was removed by distillation to afford 13 g (yield: 100%) of the target product 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenoic acid methyl ester (Compound iii) in the form of a syrupy substance.

References

[1] Patent: WO2006/17357, 2006, A1. Location in patent: Page/Page column 15
[2] Patent: WO2003/97614, 2003, A2. Location in patent: Page/Page column 8; 13
[3] Patent: CN104910078, 2017, B. Location in patent: Paragraph 0012; 0034; 0038-0040; 0046; 0052; 0058; 0064
[4] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 2, p. 437 - 444
[5] Patent: WO2006/91771, 2006, A2. Location in patent: Page/Page column 26

Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate Suppliers

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View Lastest Price from Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: 5-Oxorosuvastatin Methyl Ester 147118-39-6
Price: US $0.00-0.00/KG
Min. Order: 4KG
Purity: 99%
Supply Ability: 200
Release date: 2023-07-07

Career Henan Chemical Co

Product: Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate 147118-39-6
Price: US $1.80-3.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 88KG
Release date: 2019-09-04

147118-39-6, Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoateRelated Search:

Rosuvastatin calcium

Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate

ZD-6

Methyl 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL] -(3R,5R)-DIHYDROXY-(E)-6-HEPTENATE

Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methanesul fonylaMino) pyriMidin-5-y

(R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)-3-hydroxy-5-oxohept-6-enoate

Methyl (+)-(3R)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-(N-Methyl-NMethansulphonylaMino) pyriMidin-5-yl]-3-hydroxy-5-oxo- 6(E)-heptenoate

5-Oxorosuvastatin Methyl ester

(R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)-pyrimidin-5-yl)-3-hy

(3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester

Rosuvastatin 5-Oxo Acid Methyl Ester

Methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)pyriMidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate

Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methy

D36-C(GLS)

(R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)-pyrimidin-5-yl)-3

Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, (3R,6E)-

6(E)-heptenoate

7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-Meth...

Methyl (3R,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoate

Metamizole Sodium Impurity 4-d6（Metamizole Sodium EP Impurity D-d6）

Methyl (R,E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate

147118-39-6

C23H28FN3O6S