2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol
- Product Name
- 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol
- CAS No.
- 96145-98-1
- Chemical Name
- 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol
- Synonyms
- 2-Phenyl-5-trifluoro;1-Phenyl-3-(trifluoromethyl)-1H-pyrazol-5-ol;5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole;1H-Pyrazol-5-ol, 1-phenyl-3-(trifluoromethyl)-;3-Hydroxy-2-phenyl-5-(trifluoromethyl)pyrazole;5-Hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazole
- CBNumber
- CB2958389
- Molecular Formula
- C10H7F3N2O
- Formula Weight
- 228.17
- MOL File
- 96145-98-1.mol
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H7F3N2O/c11-10(12,13)8-6-9(16)15(14-8)7-4-2-1-3-5-7/h1-6,16H
- InChIKey
- CGMKIOXMUMZDAP-UHFFFAOYSA-N
- SMILES
- N1(C2=CC=CC=C2)C(O)=CC(C(F)(F)F)=N1
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H950920
- Product name
- 5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- H950920
- Product name
- 5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole
- Packaging
- 10g
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- HCH0011756
- Product name
- 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-OL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1365.21
- Updated
- 2021/12/16
- Product number
- 072974
- Product name
- 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol
- Purity
- 95+%
- Packaging
- 5g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- 58989
- Product name
- 5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole
- Packaging
- 1g
- Price
- $625
- Updated
- 2021/12/16
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol Chemical Properties,Usage,Production
Uses
5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole is used in the preparation 5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, an inhibitor of ADAMTS-5.
Synthesis
100-63-0
372-31-6
96145-98-1
The general procedure for the synthesis of 2-phenyl-3-hydroxy-5-trifluoromethyl-2H-pyrazole from phenylhydrazine and ethyl trifluoroacetoacetate is as follows (refer to Example 2): 1. ethyl 4,4,4-trifluoroacetoacetate (18.4 g, 0.1 mol) was dissolved in 12.0 g (0.2 mol) acetic acid. 2. the resulting solution was cooled to below 10 °C under stirring conditions. 3. 11.8 g (0.11 mol) of phenylhydrazine was slowly added dropwise to the above cooled solution over 0.5 hours. 4. after completion of the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour, then warmed up to 80°C and continued stirring for 5 hours. 5. After completion of the reaction, the reaction solution was cooled to room temperature and diluted with 100 mL of water. 6. The precipitated solid product was collected by filtration, washed twice with 50 mL of water and finally dried using a hot air dryer. 7. 22.3 g (yield: 98.0%) of the target compound 2-phenyl-3-hydroxy-5-trifluoromethyl-2H-pyrazole was obtained as light yellow crystals. LC-MS (EI): m/z = 228 (M+), melting point: 190-192 °C.
References
[1] Patent: EP1767528, 2007, A1. Location in patent: Page/Page column 11-12
[2] Journal of the American Chemical Society, 2018, vol. 140, # 12, p. 4259 - 4268
[3] Patent: WO2018/226828, 2018, A2. Location in patent: Paragraph 0220; 0221; 0222
[4] Patent: EP1364946, 2003, A1. Location in patent: Page/Page column 192
[5] Patent: US2005/256004, 2005, A1. Location in patent: Page/Page column 28
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol manufacturers
- Product
- 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol 96145-98-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18