6-Chloro-3-pyridazinecarbonitrile
- Product Name
- 6-Chloro-3-pyridazinecarbonitrile
- CAS No.
- 35857-89-7
- Chemical Name
- 6-Chloro-3-pyridazinecarbonitrile
- Synonyms
- 3-Chloro-6-cyanopyridazine;3-Chloro-6-cyanopyridazin...;6-Chloropyridazin-3-carbonitrile;6-Chloro-3-pyridazinecarbonitrile;3-Pyridazinecarbonitrile, 6-chloro-;6-Chloro-3-pyridazinecarbonitrile ISO 9001：2015 REACH
- CBNumber
- CB2958460
- Molecular Formula
- C5H2ClN3
- Formula Weight
- 139.54
- MOL File
- 35857-89-7.mol
6-Chloro-3-pyridazinecarbonitrile Property
- Melting point:
- 90-91.5 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 335.1±22.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.50±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368635
- Product name
- 6-Chloropyridazine-3-carbonitrile
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 3H37-5-75
- Product name
- 6-Chloropyridazine-3-carbonitrile
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 057945
- Product name
- 6-Chloropyridazine-3-carbonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- OR951394
- Product name
- 6-Chloro-3-pyridazinecarbonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- OR951394
- Product name
- 6-Chloro-3-pyridazinecarbonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $305
- Updated
- 2021/12/16
6-Chloro-3-pyridazinecarbonitrile Chemical Properties,Usage,Production
Uses
6-Chloropyridazine-3-carbonitrile is a reactant in the synthesis of spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors.
Synthesis
66346-83-6
35857-89-7
(1) A mixture of 6-chloropyridazine-3-carboxamide (15 g, 95.5 mmol) and pyridine (22.6 g, 23.1 mL, 286.6 mmol) was suspended in dichloromethane and cooled under argon protection to -30°C. Trifluoroacetic anhydride (TFAA) was added slowly and dropwise with stirring, keeping the temperature in the reaction system below -20°C. The reaction mixture was allowed to react at this temperature for 19.5 h. The reaction mixture was then stirred for 19.5 h. The reaction mixture was then allowed to warm up naturally to room temperature. The reaction mixture was poured into water (500 mL) and washed with water (4 x 500 mL) until the aqueous phase was light yellow. The organic phase was dried with anhydrous magnesium sulfate (MgSO?), filtered through a pad of silica gel (50 mm diameter, 30 mm height) and concentrated under reduced pressure. The resulting solid was purified by medium pressure liquid chromatography (MPLC) with an eluent of 40% dichloromethane/20 equivalents of ethyl acetate/hexane to give 6-chloro-3-pyridazinecarbonitrile as a colorless solid (5.25 g, 59% yield). Mass spectrum (EI+): m/z 139 ([M]+). NMR hydrogen spectrum (250 MHz, CDCl?) δ: 7.71 (d, J = 8 Hz, 1H); 7.83 (d, J = 8 Hz, 1H).
References
[1] Patent: US5994353, 1999, A
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3086 - 3100
[3] European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 111 - 117
6-Chloro-3-pyridazinecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-3-pyridazinecarbonitrile manufacturers
- Product
- 6-Chloro-3-pyridazinecarbonitrile 35857-89-7
- Price
- US $115.00-650.00/g
- Min. Order
- 5g
- Purity
- 99%
- Supply Ability
- 50
- Release date
- 2024-07-11
- Product
- 6-Chloro-3-pyridazinecarbonitrile 35857-89-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- 6-Chloropyridazine-3-carbonitrile 35857-89-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10