SJ6986

Product Name: SJ6986
CAS No.: 2765625-93-0
Chemical Name: SJ6986
Synonyms: SJ6986;SJ6986 ，E1300;SJ6986,SJ-6986;SJ6986, 10 mM in DMSO;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide;N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide;N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-benzenesulfonamide;Benzenesulfonamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-
CBNumber: CB29636367
Molecular Formula: C20H14F3N3O7S
Formula Weight: 497.4
MOL File: 2765625-93-0.mol

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SJ6986 Property

Density: 1.651±0.06 g/cm3(Predicted)
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
form: A crystalline solid
pka: 5.87±0.20(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: 029061
Product name: SJ6986
Packaging: 001
Price: $350
Updated: 2021/12/16

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SJ6986 Chemical Properties,Usage,Production

Description

SJ6986 is a Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degrader from a Focused Library of Cereblon Modulator.

Uses

SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1].

in vivo

SJ6986 exhibits t_1/2 of 3.44 h by iv injection of 3 mg/kg and t_max of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice^[1].

storage

Store at -20°C

References

[1] Gisele Nishiguchi, et al. Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. J Med Chem. 2021 May 27. DOI:10.1021/acs.jmedchem.0c01313

SJ6986 Preparation Products And Raw materials

Raw materials

Preparation Products

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2765625-93-0, SJ6986Related Search:

SJ6986

SJ6986,SJ-6986

Benzenesulfonamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide

N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-benzenesulfonamide

SJ6986, 10 mM in DMSO

SJ6986 ，E1300

N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide

2765625-93-0