7-Acetyl-2,3-dihydrobenzofuran

Product Name: 7-Acetyl-2,3-dihydrobenzofuran
CAS No.: 170730-06-0
Chemical Name: 7-Acetyl-2,3-dihydrobenzofuran
Synonyms: 7-Acetyl-2,3-dihydrobenzofuran;1-(2,3-Dihydro-7-benzofuranyl);1-(2,3-dihydrobenzofuran-7-yl)ethanone;1-(2,3-Dihydro-7-benzofuranyl)ethanone;Ethanone, 1-(2,3-dihydro-7-benzofuranyl);1-(2,3-dihydro-1-benzofuran-7-yl)ethanone;Ethanone, 1-(2,3-dihydro-7-benzofuranyl)- (9CI)
CBNumber: CB2966535
Molecular Formula: C10H10O2
Formula Weight: 162.19
MOL File: 170730-06-0.mol

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7-Acetyl-2,3-dihydrobenzofuran Property

Boiling point:: 295.0±29.0 °C(Predicted)
Density: 1.149±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 304930
Product name: 1-(2,3-Dihydro-7-benzofuranyl)ethanone
Packaging: 250.00mg
Price: $49
Updated: 2026/05/19

Matrix Scientific

Product number: 304930
Product name: 1-(2,3-Dihydro-7-benzofuranyl)ethanone
Packaging: 1.00g
Price: $115
Updated: 2026/05/19

Matrix Scientific

Product number: 304930
Product name: 1-(2,3-Dihydro-7-benzofuranyl)ethanone
Packaging: 5.00g
Price: $380
Updated: 2026/05/19

Synthonix

Product number: D52437
Product name: 1-(2,3-Dihydro-7-benzofuranyl)ethanone
Purity: 95+%
Packaging: 100mg
Price: $105
Updated: 2026/05/06

Synthonix

Product number: D52437
Product name: 1-(2,3-Dihydro-7-benzofuranyl)ethanone
Purity: 95+%
Packaging: 250mg
Price: $115
Updated: 2026/05/06

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7-Acetyl-2,3-dihydrobenzofuran Chemical Properties,Usage,Production

Uses

1-(2,3-Dihydro-7-benzofuranyl)ethanone is an impurity in the synthesis of Darifenacin (D193400, HBr); a medication used to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.

Synthesis

1037763-65-7

75-16-1

170730-06-0

General procedure: N-methoxy-N-methyl-2,3-dihydrobenzofuran-7-carboxylate 1b (10.9 g, 52.65 mmol) was dissolved in 150 mL of anhydrous tetrahydrofuran and degassed three times under argon protection. Subsequently, methylmagnesium bromide solution (35 mL, 3.0 M in diethyl ether, 105 mmol) was slowly added dropwise and the reaction was stirred at room temperature for 1 h to ensure complete reaction. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The pH was adjusted to 3-4 by slow dropwise addition of 1 M hydrochloric acid solution to the residue. extraction was carried out with ethyl acetate (30 mL x 4), the organic phases were combined and washed with saturated sodium chloride solution. The organic layer was dried with anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with gradient elution using elution system B. The target product 1-(2,3-dihydrobenzofuran-7-yl)ethanone 1c (6.218 g, light yellow solid) was obtained in 73.1% yield.

References

[1] Patent: CN103382206, 2016, B. Location in patent: Paragraph 0176-0179; 0184-0186

7-Acetyl-2,3-dihydrobenzofuran Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Acetyl-2,3-dihydrobenzofuran Suppliers

China 41 Europe 1 Germany 1 India 2 United Kingdom 1 United States 5 Global 51

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170730-06-0, 7-Acetyl-2,3-dihydrobenzofuranRelated Search:

7-Acetyl-2,3-dihydrobenzofuran

Ethanone, 1-(2,3-dihydro-7-benzofuranyl)- (9CI)

1-(2,3-dihydrobenzofuran-7-yl)ethanone

Ethanone, 1-(2,3-dihydro-7-benzofuranyl)

1-(2,3-Dihydro-7-benzofuranyl)ethanone

1-(2,3-Dihydro-7-benzofuranyl)

1-(2,3-dihydro-1-benzofuran-7-yl)ethanone

170730-06-0

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