4-Chloropyridine-2-carboxylic acid ethyl ester
- Product Name
- 4-Chloropyridine-2-carboxylic acid ethyl ester
- CAS No.
- 64064-56-8
- Chemical Name
- 4-Chloropyridine-2-carboxylic acid ethyl ester
- Synonyms
- Ethyl 4-chloropicolinate;Ethyl 4-chloro-2-pyridinecarboxylate;4-chloro-2-pyridinecarboxylic acid ethyl ester;2-Pyridinecarboxylic acid, 4-chloro-, ethyl ester;4-Chloropyridine-2-carboxylic acid ethyl ester ISO 9001：2015 REACH
- CBNumber
- CB2967471
- Molecular Formula
- C8H8ClNO2
- Formula Weight
- 185.61
- MOL File
- 64064-56-8.mol
4-Chloropyridine-2-carboxylic acid ethyl ester Property
- Boiling point:
- 278.6±20.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.11±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E903465
- Product name
- Ethyl4-Chloropicolinate
- Packaging
- 2.5g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- B379
- Product name
- 4-Chloropyridine-2-carboxylicacidethylester
- Packaging
- 5g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 4H23-5-2H
- Product name
- Ethyl 4-chloropicolinate
- Packaging
- 1g
- Price
- $269
- Updated
- 2021/12/16
- Product number
- HCH0029894
- Product name
- ETHYL 4-CHLOROPICOLINATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $284.55
- Updated
- 2021/12/16
- Product number
- HCH0029894
- Product name
- ETHYL 4-CHLOROPICOLINATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $981.75
- Updated
- 2021/12/16
4-Chloropyridine-2-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Uses
Ethyl 4-Chloropicolinate is a reactant in the synthesis of 1,5-naphthyridine aminothiazole and pyrazole derivatives as potent and selective inhibitors of the transforming growth factor-β type I receptor, ALK5.
Synthesis
5470-22-4
64-17-5
64064-56-8
Step-1: Synthesis of ethyl 4-chloropyridine carboxylate: 4-chloropyridine-2-carboxylic acid (20 g, 127 mmol) was mixed with thionyl chloride (200 mL), heated to 100°C and maintained for 6 hours. Upon completion of the reaction, it was cooled to room temperature and the excess thionyl chloride was removed by distillation under reduced pressure. Subsequently, ethanol (200 mL) was slowly added dropwise to the above residue at 0 °C and the resulting mixture was stirred at room temperature for 20 hours. At the end of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in ethyl acetate (1000 mL). The organic phase was washed sequentially with water (2 x 500 mL), saturated sodium bicarbonate solution (2 x 500 mL) and brine (500 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give 21.0 g (89% yield) of the target product ethyl 4-chloropyridinecarboxylate as a semi-solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.66 (d, J = 5.0 Hz, 1H), 8.13 (d, J = 2.0 Hz, 1H), 7.49 (dd, J = 5.0 and 2.0 Hz, 1H), 4.47 (q, J = 7.0 Hz, 2H), 1.46 (t, J = 7.0 Hz, 3H); GC -MS (m/z): 185,187 [M+, Cl35,37].
References
[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 10, p. 2669 - 2672
[2] Patent: WO2013/164769, 2013, A1. Location in patent: Page/Page column 48
[3] Patent: EP2119706, 2009, A1. Location in patent: Page/Page column 41
4-Chloropyridine-2-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Chloropyridine-2-carboxylic acid ethyl ester manufacturers
- Product
- 4-Chloropyridine-2-carboxylic acid ethyl ester 64064-56-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-11
- Product
- 4-Chloropyridine-2-carboxylic acid ethyl ester 64064-56-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-06
- Product
- 4-Chloropyridine-2-carboxylic acid ethyl ester 64064-56-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-08