Aceglutamide Aluminum Property

Melting point:

221° (dec)

form 

solid

Safety

Toxicity

LD50 in male mice, rats (g/kg): 14.3, >14.5 orally; 5.0, 4.2 i.p.; 0.46, 0.40 i.v. (Kagawa)

Hazard and Precautionary Statements (GHS)

Aceglutamide Aluminum Chemical Properties,Usage,Production

Originator

Glumal ,Kyowa Hakko ,Japan ,1978

Uses

Anti-ulcerative.

Definition

ChEBI: Aceglutamide aluminum is a glutamine derivative.

Manufacturing Process

A mixture of 37.6 g of N-acetyl-L-glutamine and 1,000 ml of water is heated to 40°C, and 900 ml of an isopropanol solution containing 40.8 g of aluminum isopropoxide is added to the warm mixture with stirring. The stirring is continued for 10 minutes. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. Isopropanol is added to the aqueous solution and the salt precipitates in the solution. The precipitates are collected by filtration and upon drying, 48.5 g of the crystalline-like aluminum salt of Nacetyl- L-glutamine are obtained.

brand name

Glumal (Kyowa Hakko Kogyo Co., Ltd., Japan).

Therapeutic Function

Antiulcer